Altered auditory and multisensory temporal processing in autism spectrum disorders.
Altered auditory and multisensory temporal processing in autism spectrum disorders.
复制标题
自闭症谱系障碍中听觉和多感觉时间处理的改变。
DOI：
10.3389/fnint.2010.00129
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发表时间：
2011
影响因子：
3.5
通讯作者：
Wallace MT
中科院分区：
文献类型：
--
作者：
Kwakye LD;Foss-Feig JH;Cascio CJ;Stone WL;Wallace MT
自闭症谱系障碍(ASD)的特点是缺乏社会互惠和沟通，以及重复的行为和受限的利益。对感觉输入的异常反应以及单感觉和多感觉刺激的处理中断也经常被报道。然而，ASD中感觉加工被破坏的具体方面还没有完全阐明。最近发表的研究表明，患有自闭症的儿童可以整合低水平的视听刺激，但与典型的发育中(TD)儿童相比，这样做的时间更长。然而，改变的单一感觉时间过程对已证实的多感觉功能改变的可能贡献尚不清楚。在目前的研究中，通过确定视觉和听觉时间顺序判断(TOJ)任务的个体阈值来测量单感觉时间敏锐度，并通过TOJ任务的跨通道版本来评估多感觉时间功能。ASD和TD儿童在视觉TOJ任务上的阈值没有差异，而ASD儿童在听觉TOJ任务上的阈值更高，这为听觉时间加工障碍提供了初步证据。在多感觉TOJ任务中，与TD儿童相比，ASD儿童在更广泛的时间间隔内表现出更高的表现，这加强了先前的工作，表明ASD儿童的多感觉整合的时间窗口延长了。这些发现有助于更好地理解基本的感觉加工差异，这可能是理解ASD中更复杂的社会和认知缺陷的关键，并最终可能有助于更有效的诊断和干预策略。
Autism spectrum disorders (ASD) are characterized by deficits in social reciprocity and communication, as well as by repetitive behaviors and restricted interests. Unusual responses to sensory input and disruptions in the processing of both unisensory and multisensory stimuli also have been reported frequently. However, the specific aspects of sensory processing that are disrupted in ASD have yet to be fully elucidated. Recent published work has shown that children with ASD can integrate low-level audiovisual stimuli, but do so over an extended range of time when compared with typically developing (TD) children. However, the possible contributions of altered unisensory temporal processes to the demonstrated changes in multisensory function are yet unknown. In the current study, unisensory temporal acuity was measured by determining individual thresholds on visual and auditory temporal order judgment (TOJ) tasks, and multisensory temporal function was assessed through a cross-modal version of the TOJ task. Whereas no differences in thresholds for the visual TOJ task were seen between children with ASD and TD, thresholds were higher in ASD on the auditory TOJ task, providing preliminary evidence for impairment in auditory temporal processing. On the multisensory TOJ task, children with ASD showed performance improvements over a wider range of temporal intervals than TD children, reinforcing prior work showing an extended temporal window of multisensory integration in ASD. These findings contribute to a better understanding of basic sensory processing differences, which may be critical for understanding more complex social and cognitive deficits in ASD, and ultimately may contribute to more effective diagnostic and interventional strategies.