Influence of dendritic structure on firing pattern in model neocortical neurons
Influence of dendritic structure on firing pattern in model neocortical neurons
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DOI：
10.1038/382363a0
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发表时间：
1996-07-25
期刊：
影响因子：
64.8
通讯作者：
Sejnowski, TJ
中科院分区：
文献类型：
--
作者：
Mainen, ZF;Sejnowski, TJ
新皮质神经元表现出广泛的树突形态，从紧凑的树突到高度复杂的分支模式(1)。这些神经元的体外电记录显示了相应的多种内在放电模式，包括非适应型、适应型和爆发型（2,3）。这种电响应性的异质性通常归因于离子通道类型和密度的可变性。我们在这里展示了，使用重建皮层神经元的室室模型，整个放电模式的频谱可以在一组神经元中重现，这些神经元共享一个共同的离子通道分布，只是树突几何形状不同。该模型的基本行为取决于局部定位于体细胞和轴突的快速有源电导和位于整个树突的慢有源电流的部分电耦合，并且可以在双室模型中重现。结果表明，观察到的树突结构和放电特性之间存在因果关系（3-7），并强调了活跃的树突电导在神经元功能中的重要性（8-10）。
NEOCORTICAL neurons display a wide range of dendritic morphologies, ranging from compact arborizations to highly elaborate branching patterns(1). In vitro electrical recordings from these neurons have revealed a correspondingly diverse range of intrinsic firing patterns, including non-adapting, adapting and bursting types(2,3). This heterogeneity of electrical responsivity has generally been attributed to variability in the types and densities of ionic channels. We show here, using compartmental models of reconstructed cortical neurons, that an entire spectrum of firing patterns can be reproduced in a set of neurons that share a common distribution of ion channels and differ only in their dendritic geometry. The essential behaviour of the model depends on partial electrical coupling of fast active conductances localized to the soma and axon and slow active currents located throughout the dendrites, and can be reproduced in a two-compartment model. The results suggest a causal relationship for the observed correlations between dendritic structure and firing properties(3-7) and emphasize the importance of active dendritic conductances in neuronal function(8-10).