A case of bipolar disorder with AIF1 (coding gene of Iba-1) deletion: A pilot in vitro analysis using blood-derived microglia-like cells
A case of bipolar disorder with AIF1 (coding gene of Iba-1) deletion: A pilot in vitro analysis using blood-derived microglia-like cells
复制标题
AIF1（Iba-1 编码基因）缺失的双相情感障碍病例：使用血源性小胶质细胞样细胞进行的体外试验分析
DOI：
10.1111/pcn.13505
复制
发表时间：
2022
影响因子：
11.9
通讯作者：
Kato Takahiro A
中科院分区：
文献类型：
--
作者：
Ohgidani Masahiro;Kushima Itaru;Inamine Shogo;Kyuragi Sota;Sagata Noriaki;Nakao Tomohiro;Kanba Shigenobu;Ozaki Norio;Kato Takahiro A
在来自HC的iMG细胞中鉴定出具有延伸突起的分支细胞，然而，几乎所有来自IAIF 1 i缺陷患者的细胞都具有圆形形态（图AIF 1（Iba-1的编码基因）缺失的双相情感障碍病例：使用血液来源的小胶质细胞样细胞进行体外试验分析小胶质细胞，大脑中的免疫细胞，已被强调，以了解各种精神疾病，包括精神分裂症和情绪障碍的病理生理学。[[1]]离子化钙结合衔接分子1（Iba-1），由IAIF 1 i（同种异体移植炎症因子1）基因编码（6 p21. 33），是一种在小胶质细胞中表达的蛋白质，是最知名的小胶质细胞标志物。[3]我们在此提出了第一例双相情感障碍与I AIF 1 i缺陷（6p 21。33缺失），并显示了该患者中小胶质细胞相关功能的体外分析。精神病学和临床神经科学的版权是Wiley-Blackwell的财产，未经版权保持器的明确书面许可，其内容不得复制或通过电子邮件发送到多个网站或发布到列表服务器。但是，用户可以打印，下载或电子邮件的文章供个人使用。这篇摘要可以删节。不保证副本的准确性。用户应参考原始出版版本的材料的完整摘要。版权适用于所有摘要。
Ramified cells with extended processes were identified in the iMG cells from the HC, However, almost all cells derived from the patient with I AIF1 i deficiency had rounded morphology (Fig. A case of bipolar disorder with AIF1 (coding gene of Iba-1) deletion: A pilot in vitro analysis using blood-derived microglia-like cells Microglia, immune cells in the brain, have been highlighted to understand the pathophysiology of various psychiatric disorders including schizophrenia and mood disorders.[[1]] Ionized calcium-binding adapter molecule 1 (Iba-1), encoded by the I AIF1 i (allograft inflammatory factor 1) gene (6p21. 33), is a protein expressed in microglia and is the best-known microglial marker.[3] We herein present the first case of bipolar disorder with I AIF1 i deficiency (6p21. 33 deletion), and show the pilot I in vitro i analysis of microglia-related functions in this patient.[Extracted from the article]Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.