CELLULAR-RESPONSE TO ANDROGEN DEPLETION AND REPLETION IN THE RAT VENTRAL PROSTATE - AUTORADIOGRAPHY AND MORPHOMETRIC ANALYSIS
CELLULAR-RESPONSE TO ANDROGEN DEPLETION AND REPLETION IN THE RAT VENTRAL PROSTATE - AUTORADIOGRAPHY AND MORPHOMETRIC ANALYSIS
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DOI：
10.1002/pros.2990070106
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发表时间：
1985-01-01
期刊：
影响因子：
2.8
通讯作者：
SANTEN, RJ
中科院分区：
文献类型：
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作者：
ENGLISH, HF;DRAGO, JR;SANTEN, RJ
利用光镜放射自显影和形态计量学分析研究了雄激素耗竭/补充对大鼠腹侧前列腺细胞类型的影响。将所有前列腺细胞分配到以下组中的一组：上皮、内皮、基质（腺泡周围）或基质（腺泡间）。除后一组外，所有其他细胞类型的数量显着减少雄激素耗竭（去势），并增加了充满之后。在补充期间，所有类型的细胞的标记指数平行上升，并在开始雄激素替代后72小时达到峰值。测定刚好在峰值日之前的增殖池的大小。总前列腺细胞群的45%被发现被标记。上皮细胞组的标记细胞的比例最大，但显着的百分比发生在其他类型。这些结果精确地定义了雄激素替代对去势大鼠前列腺细胞群体动力学的时间效应。
The effect of androgen depletion/repletion on the cell types of the rat ventral prostate has been studied using light microscope autoradiography and morphometric analysis. All prostatic cells were assigned to 1 of the following groups: epithelial, endothelial, stromal (periacinar), or stromal (interacinar). With the exception of the latter group, the numbers of all other cell types were significantly reduced by androgen depletion (castration), and increased by repletion thereafter. During the repletion period, the labeling index of all cell types rose in parallel and peaked 72 h postinitiation of androgen replacement. The size of the proliferating pool just prior to the peak day was determined. Of the total prostatic cell population 45% was found to be labeled. The epithelial cell group contained the greatest proportion of labeled cells, but significant percentages occurred in the other types. These results precisely define the temporal effects of androgen replacement on prostatic cell population dynamics in the castrate rat.