Morphological control and in vitro bioactivity of nanoscale bioactive glasses
Morphological control and in vitro bioactivity of nanoscale bioactive glasses
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纳米级生物活性玻璃的形态控制及体外生物活性
DOI：
10.1016/j.jnoncrysol.2009.02.005
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发表时间：
2009-05-15
影响因子：
3.5
通讯作者：
Zhao, Naru
中科院分区：
文献类型：
--
作者：
Chen, Xiaofeng;Lei, Bo;Zhao, Naru
本研究以乳酸为水解促进剂，采用溶胶-凝胶法制备了不同形貌的纳米生物活性玻璃。研究了乳酸浓度对生物活性玻璃形貌的影响。在模拟体液中考察了形态对样品体外生物活性的影响，并采用多种方法进行了检测。结果表明，纳米表面形貌与高粗糙度，通过添加乳酸，大大提高了体外生物活性的制备样品。结果表明，除了比表面积和孔容外，具有纳米级表面特征和孔径分布的形貌对碳酸化羟基磷灰石的形成起着重要的促进作用。根据我们的研究结果，具有显著数量的纳米级生物活性玻璃颗粒和狭窄的单峰或双峰介孔结构的表面形态的生物活性玻璃，表现出最好的体外生物活性。(C)2009 Elsevier B. V.保留所有权利。
In this study, nanoscale bioactive glasses with different morphologies were prepared through sol-gel process using lactic acid as hydrolysis promoter. The effect of lactic acid concentration on the morphology of bioactive glass was characterized. The influence of the morphology on the in vitro bioactivity of samples was investigated in simulated body fluid and examined by various methods. The results showed that nanoscale surface morphologies with high roughness, created by addition of lactic acid, greatly enhanced the in vitro bioactivity of as-prepared samples. It was found that the morphology with nanoscale Surface feature and pore size distribution, in addition to specific surface area and pore volume, plays an important role in accelerating the formation of carbonated hydroxyapatite. According to our results, bioactive glasses possessing surface morphology with significant numbers of nanoscale bioactive glass particles and a narrow unimodal or bimodal mesopore structure, exhibit the best in vitro bioactivity. (C) 2009 Elsevier B.V. All rights reserved.