4-aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the European prospective investigation into cancer and nutrition prospective study
4-aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the European prospective investigation into cancer and nutrition prospective study
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DOI：
10.1158/1055-9965.epi-05-0150
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发表时间：
2005-09-01
影响因子：
3.8
通讯作者：
Riboli, E
中科院分区：
文献类型：
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作者：
Airoldi, L;Vineis, P;Riboli, E
本研究的目的是评估环境烟草烟雾暴露的生物标志物[i]。[0,4 -氨基联苯-血红蛋白（4-ABP-Hb）加合物]可预测烟草相关癌症和疾病的风险。我们在欧洲癌症和营养前瞻性调查中进行了一项病例对照研究，涉及190例对照和149例病例（肺癌、膀胱癌、咽喉癌、口腔癌、白血病和慢性阻塞性肺病或肺气肿死亡）。所有的人在10 - 10年内从不吸烟或曾经吸烟。在发病前（中位，7年）收集外周血分析4-ABP-Hb加合物。总的来说，4-ABP-Hb加合物比对照组高，尽管在统计学上没有显著性差异。在对照人群中，大量食用水果和蔬菜显著降低了可检测加合物的频率（Fisher精确检验，P = 0.025）。将分析限制在女性中，病例中4-ABP-Hb加合物高于对照组（Mann-Whitney P = 0.036），加合物存在/不存在的优势比（OR）为2.42[95%可信区间（95% CI）， 1.18-4.981]。此外，成人与个体癌症类型的关联在女性中比在整个研究人群中更强，尽管只有白血病具有统计学意义（OR, 2.77; 95% CI, 1.06-7.20）。研究结果提供了一些证据，表明女性可能更容易受到环境烟草烟雾的影响，因为她们的成人水平较高。这项前瞻性研究最重要的发现是，至少在女性中，4-ABP-Hb加成物可能有助于识别与环境烟草烟雾暴露相关的癌症高风险受试者。
The aim of this study was to evaluate whether biomarkers of environmental tobacco smoke exposure [i.e, 4-aminobiphenyl-hemoglobin (4-ABP-Hb) adducts] were predictive of the risk of tobacco-related cancers and diseases. We did a case control study nested within the European Prospective Investigation into Cancer and Nutrition, involving 190 controls and 149 cases (incident cancer of the lung, bladder, pharynx, larynx, oral cavity, leukemias, and chronic obstructive pulmonary disease or emphysema deaths). All individuals were never smokers or ex smokers for > 10 years. 4-ABP-Hb adducts were analyzed in peripheral blood collected before the onset of the disease (median, 7 years). Overall, 4-ABP-Hb adducts were higher, although not statistically significantly so, in cases (as a whole) than controls. In the control population, high fruit and vegetable consumption significantly lowered the frequency of detectable adducts (Fisher's exact test, P = 0.025). Restricting the analysis to women, 4-ABP-Hb adducts were higher in cases than controls (Mann-Whitney P = 0.036) and the odds ratio (OR) for the presence/absence of adducts was 2.42 [95% confidence interval (95% CI), 1.18-4.981. Moreover, the association of adducts with the individual cancer types was stronger in women than in the whole study population, although statistically significant only for leukemias (OR, 2.77; 95% CI, 1.06-7.20). The results provide some evidence that women may be more susceptible to environmental tobacco smoke, as suggested by their higher adduct levels. The most important finding of this prospective study is that, at least in women, 4-ABP-Hb adducts may help identify subjects at high risk of cancers related to environmental tobacco smoke exposure.