Few-Layer Graphene Kills Selectively Tumor Cells from Myelomonocytic Leukemia Patients
Few-Layer Graphene Kills Selectively Tumor Cells from Myelomonocytic Leukemia Patients
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DOI：
10.1002/anie.201700078
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发表时间：
2017-03-06
影响因子：
16.6
通讯作者：
Delogu, Lucia G.
中科院分区：
文献类型：
--
作者：
Russier, Julie;Leon, Verolinica;Delogu, Lucia G.
癌症是当今死亡率的主要原因，在癌症的治疗中，化疗是最常见的治疗方法，尽管目前的抗癌药物经常遇到严重的挑战。我们发现，几层石墨烯（FLG）分散体对单核细胞具有特定的杀伤作用，对其他免疫细胞既没有毒性也没有激活作用。我们证实了石墨烯在一种侵袭性癌症上的治疗应用，这种癌症是骨髓单核细胞白血病，其中单核细胞处于其恶性形式。我们证明了石墨烯具有独特的靶向和特异性促进单核细胞癌细胞坏死的能力。此外，FLG与常用化疗药物依托泊苷的比较证实了FLG具有更高的特异性和毒性。由于目前白血病的化疗治疗仍然会引起严重的问题，这些发现为新的更安全的治疗方法开辟了道路。
In the cure of cancer, a major cause of today's mortality, chemotherapy is the most common treatment, though serious frequent challenges are encountered by current anticancer drugs. We discovered that few-layer graphene (FLG) dispersions have a specific killer action on monocytes, showing neither toxic nor activation effects on other immune cells. We confirmed the therapeutic application of graphene on an aggressive type of cancer that is myelomonocytic leukemia, where the monocytes are in their malignant form. We demonstrated that graphene has the unique ability to target and boost specifically the necrosis of monocytic cancer cells. Moreover, the comparison between FLG and a common chemotherapeutic drug, etoposide, confirmed the higher specificity and toxicity of FLG. Since current chemotherapy treatments of leukemia still cause serious problems, these findings open the way to new and safer therapeutic approaches.