Sleep spindles in human prefrontal cortex: an electrocorticographic study
Sleep spindles in human prefrontal cortex: an electrocorticographic study
复制标题
DOI：
10.1016/s0168-0102(03)00007-5
复制
发表时间：
2003-04-01
影响因子：
2.9
通讯作者：
Shimizu, H
中科院分区：
文献类型：
--
作者：
Nakamura, M;Uchida, S;Shimizu, H
为了研究人类前额叶皮层（PFC）的睡眠纺锤体活动，我们同时记录了癫痫患者在自然睡眠过程中整晚的多导睡眠图和皮质电图（ECoG）活动。研究对象为9例顽固性癫痫患者，他们将硬膜下电极手术连接到眶部（7例）、内侧（3例）或背外侧（2例）PFC， 1例连接到额极。为了检查主轴频率，对PFC ECoG和Cz EEG数据进行了快速傅里叶变换（FFT）和自相关分析，主要是在第二阶段睡眠的时期。低西格玛频带的脑电图振荡广泛分布在包括额叶边缘在内的所有前额皮质区域，但PFC西格玛频带的频率峰值都与更快的（约14 Hz） Cz脑电图睡眠纺锤波不一致。结合我们的研究结果与解剖学和电生理学事实，我们认为涉及丘脑吻侧网状核和中背侧核的丘脑额叶回路负责人类12赫兹额叶纺锤波的产生。(C) 2003爱思唯尔科学爱尔兰有限公司和日本神经科学学会。版权所有。
To investigate the sleep spindle activity of the human prefrontal cortex (PFC), we simultaneously recorded whole nights of polysomnographic and electrocorticographic (ECoG) activities during the natural sleep of epileptic patients. Subjects were nine patients with intractable epilepsy who had subdural electrodes surgically attached to the orbital (seven cases), medial (three cases), or dorsolateral (two cases) PFC, and in one case to the frontal pole. To examine spindle frequencies, fast Fourier transformation (FFT) and auto-correlation analyses were performed on the PFC ECoG and Cz EEG data, primarily on epochs of stage 2 sleep. Lower sigma band ECoG oscillations of about 12 Hz were widely distributed across all prefrontal cortical areas including the frontal limbic regions, but none of the PFC sigma frequency peaks coincided with the faster (about 14 Hz) Cz EEG sleep spindles. Combining our results with anatomical and electrophysiological facts, it is suggested that the thalamofrontal circuit involving the rostral reticular and the mediodorsal nucleus of the thalamus is responsible for the generation of 12 Hz frontal spindles in humans. (C) 2003 Elsevier Science Ireland Ltd. and the Japan Neuroscience Society. All rights reserved.