Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns
Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns
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DOI：
10.1073/pnas.95.6.3071
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发表时间：
1998-03-17
影响因子：
11.1
通讯作者：
Waltenbaugh, C
中科院分区：
文献类型：
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作者：
Peterson, JD;Herzenberg, LA;Waltenbaugh, C
目前的观点将免疫反应中辅助性 T 细胞 1 (Th1) 和 Th2 细胞因子反应模式之间的平衡归因于抗原的性质、宿主的遗传组成以及参与 T 细胞和抗原呈递细胞之间早期相互作用的细胞因子。在这里，我们介绍谷胱甘肽，一种调节细胞内氧化还原和细胞生理学其他方面的三肽，作为该过程中的关键调节元件。通过使用三种不同的方法来消耗 T 细胞受体转基因小鼠和传统小鼠中的谷胱甘肽，并研究对三种不同抗原的体内和/或体外反应，我们发现抗原呈递细胞中的谷胱甘肽水平决定了 Th1 或 Th2 反应模式是否占主导地位。这些发现为艾滋病毒和其他疾病的免疫反应改变提供了新的见解。此外，它们还可能为“Th1”和“Th2”小鼠品系中众所周知的免疫反应差异提供解释。
Current thinking attributes the balance between T helper 1 (Th1) and Th2 cytokine response patterns in immune responses to the nature of the antigen, the genetic composition of the host, and the cytokines involved in the early interaction between T cells and antigen-presenting cells. Here we introduce glutathione, a tripeptide that regulates intracellular redox and other aspects of cell physiology, as a key regulatory element in this process. By using three different methods to deplete glutathione from T cell receptor transgenic and conventional mice and studying in vivo and/or in vitro responses to three distinct antigens, we show that glutathione levels in antigen-presenting cells determine whether Th1 or Th2 response patterns predominate. These findings present new insights into immune response alterations in HIV and other diseases. Further, they potentially offer an explanation for the well known differences in immune responses in "Th1" and "Th2" mouse strains.