Comparison of percutaneous 915 MHz microwave ablation and 2450 MHz microwave ablation in large hepatocellular carcinoma
Comparison of percutaneous 915 MHz microwave ablation and 2450 MHz microwave ablation in large hepatocellular carcinoma
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DOI：
10.3109/02656731003717574
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发表时间：
2010-01-01
影响因子：
3.1
通讯作者：
Yu, Jie
中科院分区：
文献类型：
--
作者：
Liu, Fang-Yi;Yu, Xiao-Ling;Yu, Jie
目的：比较超声（US）引导经皮915 MHz微波（MW）消融与2450 MHz MW消融治疗大肝癌（HCC）的有效性（直径>4厘米）。2007年3月至2008年12月期间接受超声引导下经皮微波消融治疗的直径>4 cm的HCC患者（39）随机分为915 MHz微波组和2450 MHz微波组。我们比较了两组之间的消融结果。结果：在915 MHz MW组（3.69 +/- 0.6）比2450 MHz MW组（4.71 +/- 1.61）（p = 0.01），每个肿瘤需要较少的天线插入。根据随访对比增强成像，915 MHz MW组和2450 MHz MW组的技术有效率分别为85.7%（18/21）和73.7%（14/19）（p = 0.44）。915 MHz MW组和2450 MHz MW组的局部肿瘤进展（LTP）率分别为14.3%（3/21）和26.3%（5/19）（p = 0.44）。有没有死亡，没有血栓形成的主要血管在任何patient.Conclusions：与2450 MHz微波消融相比，我们的初步经验表明，经皮915 MHz微波消融与冷却轴天线是安全的，可以达到较高的技术有效率与较少的插入数在治疗大肝癌。因此，经皮915 MHz微波消融可能为大肝癌的治疗提供一种新的方法。
Purpose: To compare the effectiveness of ultrasound (US)-guided percutaneous 915 MHz microwave (MW) ablation with the 2450 MHz MW ablation for large hepatocellular carcinoma (HCC) (>4 cm in diameter).Materials and methods: Patients with HCC >4 cm in diameter who underwent US-guided percutaneous MW ablation with curative intention between March 2007 and December 2008 (39) were randomly divided into two groups, 915 MHz MW group and 2450 MHz MW group. We compared the results of ablation between the two groups.Results: Fewer antenna insertions for each tumour were required in the 915 MHz MW group (3.69 +/- 0.6) than in the 2450 MHz MW group (4.71 +/- 1.61) (p = 0.01). According to the follow-up contrast-enhanced imagings, technique effectiveness rate was 85.7% (18/21) and 73.7% (14/19) in the 915 MHz MW group and 2450 MHz MW group, respectively (p = 0.44). The rate of local tumour progression (LTP) was 14.3% (3/21) and 26.3% (5/19) in the 915 MHz MW group and 2450 MHz MW group, respectively (p = 0.44). There were no deaths and no thrombosis of major vessels in any patient.Conclusions: Compared with 2450 MHz MW ablation, our initial experience showed that percutaneous 915 MHz MW ablation with cooled-shaft antennae was safe and could achieve a high technique effectiveness rate with fewer insertion numbers in the treatment of large HCC. Therefore, percutaneous 915 MHz MW ablation may provide a new method for the treatment of large HCC.