RHO, RAC AND CDC42 GTPASES - REGULATORS OF ACTIN STRUCTURES, CELL-ADHESION AND MOTILITY
RHO, RAC AND CDC42 GTPASES - REGULATORS OF ACTIN STRUCTURES, CELL-ADHESION AND MOTILITY
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DOI：
10.1042/bst0230456
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发表时间：
1995-08-01
影响因子：
3.9
通讯作者：
HALL, A
中科院分区：
文献类型：
--
作者：
NOBES, CD;HALL, A
哺乳动物小GTP酶rho亚家族包含9种蛋白质（rhoA、B、C、racl和2、cdc 42和GdPK、rho G和TC 10）。rho蛋白生物学功能的第一条线索来自于观察到细菌胞外酶C3转移酶（ADP-核糖基化并使rho蛋白失活）导致动物细胞失去肌动蛋白
The mammalian rho subfamily of small GTPases comprises nine proteins (rhoA, B, C, racl and 2, cdc42 and GZSK, rho G and TC10). The first clue to a biological function for rho proteins came from the observation that the bacterial exoenzyme, C3 transferase, which ADP-ribosylates and inactivates rho proteins, causes animal cells to lose their actin