The central insulin system and energy balance.
The central insulin system and energy balance.
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DOI：
10.1007/978-3-642-24716-3_5
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Woods, Stephen C
中科院分区：
文献类型：
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作者：
Begg, Denovan P;Woods, Stephen C
胰岛素在全身起作用，减少循环能量并增加能量储存。在脑内，胰岛素通过减少食物摄入和增加能量消耗产生净分解代谢效应;这通过中枢胰岛素输注诱导的摄食量减少和棕色脂肪组织交感神经活动增加来证明。通过施用胰岛素抗体、受体反义治疗或受体敲低来降低脑胰岛素系统的活性导致摄食过多和肥胖增加。然而，尽管对中枢胰岛素在食物摄入中的作用进行了数十年的研究，但仍有许多问题有待回答，包括潜在的作用机制。
Insulin acts throughout the body to reduce circulating energy and to increase energy storage. Within the brain, insulin produces a net catabolic effect by reducing food intake and increasing energy expenditure; this is evidenced by the hypophagia and increased brown adipose tissue sympathetic nerve activity induced by central insulin infusion. Reducing the activity of the brain insulin system via administration of insulin antibodies, receptor antisense treatment, or receptor knockdown results in hyperphagia and increased adiposity. However, despite decades of research into the role of central insulin in food intake, many questions remain to be answered, including the underlying mechanism of action.