Interferon-α effects are exaggerated when administered on a psychosocial stressor backdrop:: Cytokine, corticosterone and brain monoamine variations
Interferon-α effects are exaggerated when administered on a psychosocial stressor backdrop:: Cytokine, corticosterone and brain monoamine variations
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DOI：
10.1016/j.jneuroim.2007.02.008
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发表时间：
2007-05-01
影响因子：
3.3
通讯作者：
Hayley, Shawn
中科院分区：
文献类型：
--
作者：
Anisman, Hymie;Poulter, Michael O.;Hayley, Shawn
涉及干扰素-α (IFN-α) 治疗的免疫疗法通常伴有抑郁症症状。这些效应可能源于细胞因子的直接作用，或者可能是承受相当大压力的个体所独有的。在使用 CD-1 小鼠的两项实验中，我们证明腹膜内给予 IFN-α 剂量依赖性地影响血浆皮质酮和疾病行为，并适度影响大脑中去甲肾上腺素的周转。然而，当小鼠暴露于社会心理压力源（通过将小鼠从隔离环境转移到分组环境，以及在一定程度上将小鼠从分组环境转移到隔离环境而造成社会破坏）时，IFN-α对疾病、血浆皮质酮和海马去甲肾上腺素以及循环IL-6、TNF-α和IL-10（但不包括IL-1β或IFN-γ）水平的影响大大增强。有人认为，免疫疗法对人类的抑郁作用同样反映了细胞因子的协同作用和患者所经历的持续痛苦。 (c) 2007 Elsevier B.V. 保留所有权利。
Immunotherapy involving interferon-a (IFN-alpha) treatment is often accompanied by symptoms of depressive illness. These effects may stem from the direct actions of the cytokine, or may be unique to individuals undergoing considerable strain. In two experiments using CD-1 mice, we demonstrate that intraperitoneal administration of IFN-alpha dose dependently influences plasma corticosterone and sickness behaviors, and modestly influences norepinephrine turnover in brain. However, when mice are exposed to a psychosocial stressor (social disruption by transferring mice from isolated to grouped conditions, and to a moderate extent a transfer from grouped housing to isolation), the effects of IFN-alpha on sickness, plasma corticosterone and hippocampal norepinephrine, as well as on the levels of circulating IL-6, TNF-alpha and IL-10 (but not IL-1 beta or IFN-gamma) are greatly augmented. It is suggested that the depressive effects of immunotherapy in humans likewise reflects the synergistic actions of the cytokine and the ongoing distress experienced by patients. (c) 2007 Elsevier B.V. All rights reserved.