Genetic markers as instrumental variables.
Genetic markers as instrumental variables.
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DOI：
10.1016/j.jhealeco.2015.10.007
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发表时间：
2016-01
影响因子：
3.5
通讯作者：
Windmeijer F
中科院分区：
文献类型：
--
作者：
von Hinke S;Davey Smith G;Lawlor DA;Propper C;Windmeijer F
使用遗传标记作为工具变量(IV)正受到经济学家、统计学家、流行病学家和社会科学家越来越多的关注。虽然IV在经济学中普遍使用，但使用遗传变异作为工具的适当条件还没有得到很好的定义。然而，生物医学数据的日益可获得性使得对这些条件的理解对于成功地使用基因类型作为工具至关重要。我们结合计量经济学的IV文献和遗传流行病学的文献，并在统计潜在结果框架内讨论生物学条件和IV假设。我们在两个说明性应用程序的背景下回顾这一点。
The use of genetic markers as instrumental variables (IV) is receiving increasing attention from economists, statisticians, epidemiologists and social scientists. Although IV is commonly used in economics, the appropriate conditions for the use of genetic variants as instruments have not been well defined. The increasing availability of biomedical data, however, makes understanding of these conditions crucial to the successful use of genotypes as instruments. We combine the econometric IV literature with that from genetic epidemiology, and discuss the biological conditions and IV assumptions within the statistical potential outcomes framework. We review this in the context of two illustrative applications.