COMPARISON OF SINGLE DRUSEN SIZE ON COLOR FUNDUS PHOTOGRAPHY AND SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY
COMPARISON OF SINGLE DRUSEN SIZE ON COLOR FUNDUS PHOTOGRAPHY AND SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY
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DOI：
10.1097/iae.0000000000003099
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发表时间：
2021-08-01
影响因子：
3.3
通讯作者：
Jaffe, Glenn J.
中科院分区：
文献类型：
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作者：
Kim, Dong Yoon;Loo, Jessica;Jaffe, Glenn J.
目的：确定通过光谱域光学相干断层扫描（SD-OCT）确定的玻璃疣大小与在注册彩色眼底摄影（CFP）图像上测量的玻璃疣大小的关系，并推导出与CFP确定的玻璃疣大小相当的基于OCT的分类系统。研究方法：自定义软件的开发注册CFP图像扫描激光检眼镜眼底图像同时获得相应的SD-OCT图像，使CFP上观察到的个体玻璃疣可以与SD-OCT. Single druse大小（直径，面积，体积和高度）上看到的SD-OCT图像从第二阶段临床试验确定与杜克OCT视网膜分析程序。结果如下：对213例玻璃疣进行CFP和SD-OCT测量，CFP测量的玻璃疣直径与SD-OCT测量的玻璃疣直径呈显著正相关（R：0.879，P < 0.001）。根据相应的公式：SD-OCT上的玻璃疣直径= 0.77 x（CFP上的玻璃疣直径）+50.67 μ m，CFP上定义为≥ 125 μ m的大玻璃疣在OCT上的直径≥ 145 μ m，CFP上定义为63 μ m至124 μ m的中等玻璃疣在OCT上的直径为100 μ m至144 μ m，CFP上定义为μ m的小玻璃疣在OCT上的直径为μ m。通过我们的配准软件和图像处理算法，我们能够将CFP上测量的个体晶簇大小与SD-OCT上确定的个体晶簇大小相关联。这些数据可用于开发基于SD-OCT的分级量表，类似于可用于临床和临床试验的CFP视网膜相关眼病研究玻璃疣量表。
Purpose: To determine the relationship of drusen size as determined by spectral-domain optical coherence tomography (SD-OCT) with that measured on registered color fundus photography (CFP) images and to derive an OCT-based classification system that was comparable with that determined by CFP. Methods: Custom software was developed to register CFP images to the scanning laser ophthalmoscopy fundus images obtained simultaneously with the corresponding SD-OCT images, so that individual drusen observed on CFP could be matched with those seen on SD-OCT. Single druse size (diameter, area, volume, and height) on CFP and SD-OCT images from a phase two clinical trial was determined with the Duke OCT Retinal Analysis Program. Results: The sizes of 213 individual drusen were measured on CFP and SD-OCT. The drusen diameter measured on CFP was significantly correlated with those determined on SD-OCT (R: 0.879, P < 0.001). Based on the corresponding formula: drusen diameter on SD-OCT = 0.77 x (drusen diameter on CFP) + 50.67 mu m, large drusen defined as >= 125 mu m on CFP had a diameter >= 145 mu m on OCT, medium drusen defined as 63 mu m to 124 mu m on CFP had diameters 100 mu m to 144 mu m on OCT, and small drusen defined as mu m on CFP had diameters mu m on OCT. Conclusion: With our registration software and imaging processing algorithms, we were able to correlate individual druse sizes measured on CFP with those determined on SD-OCT. These data can be used to develop an SD-OCT-based grading scale, analogous to the CFP Age-Related Eye Disease Study drusen scale that may be useful in the clinic and in clinical trials.