Basal lamina assembly.
Basal lamina assembly.
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基底层组件。
DOI：
10.1016/0955-0674(94)90093-0
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发表时间：
1994
影响因子：
7.5
通讯作者：
O'Rear,JJ
中科院分区：
文献类型：
--
作者：
Yurchenco,PD;O'Rear,JJ
通过对“经典”组分的研究，建立了理想基板的装配和结构模型。特别是，这些证据支持了胶原蛋白和层粘连蛋白聚合物的概念，在这些聚合物中，内氮素/粘连蛋白作为这些分子之间的桥梁，并为各种基质成分提供锚定。然而，不同的基底膜具有不同的基本基底膜家族成员，如新发现的α(IV)胶原蛋白、α2（merosin）层粘连蛋白和β3层粘连蛋白（kalinin/nicein）链。尽管这些成员共享同源结构域和序列，并且可能共享某些功能，但它们也具有独特的特征，预计会提供基层异质性。目前正在应用遗传、重组和生化方法相结合的方法来阐明新旧成分的特殊作用。
From studies of the ‘classical’ components, models for the assembly and structure of an idealized basal lamina have been developed. In particular, the evidence supports the concept of enmeshed collagen and laminin polymers, in which nidogen/entactin acts as a bridge between these molecules and provides anchorage for diverse matrix components. Different basement membranes, however, possess different members of the basic basal lamina families, such as the newly described α(IV) collagen, α2(merosin) laminin, and β3 laminin (in kalinin/nicein) chains. Even though these members share homologous domains and sequences, and are likely to share certain functions, they also possess unique characteristics that are expected to provide for basal lamina heterogeneity. A combination of genetic, recombinant and biochemical approaches are now being applied to elucidate the special roles of both old and new components.