Posaconazole Mono- or Combination Therapy for Treatment of Murine Zygomycosis
Posaconazole Mono- or Combination Therapy for Treatment of Murine Zygomycosis
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DOI：
10.1128/aac.01124-08
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发表时间：
2009-02-01
影响因子：
4.9
通讯作者：
Spellberg, Brad
中科院分区：
文献类型：
--
作者：
Ibrahim, Ashraf S.;Gebremariam, Teclegiorgis;Spellberg, Brad
We compared the efficacy of combination posaconazole-liposomal amphotericin B (LAmB) therapy to monotherapy with either drug in diabetic ketoacidotic or neutropenic mice with disseminated zygomycosis caused by Rhizopus oryzae. Combination therapy was no better than LAmB alone, and posaconazole monotherapy did not improve survival or reduce fungal burden versus placebo.
