REM sleep behavior disorder in Parkinson's disease and dementia with Lewy bodies
REM sleep behavior disorder in Parkinson's disease and dementia with Lewy bodies
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DOI：
10.1177/0891988704267465
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发表时间：
2004-09-01
影响因子：
2.6
通讯作者：
Ferman, TJ
中科院分区：
文献类型：
--
作者：
Boeve, BF;Silber, MH;Ferman, TJ
快速眼动（REM）睡眠行为障碍（RBD）是一种睡眠异常，表现为在REM睡眠期间与简单或复杂运动行为相关的生动，经常令人恐惧的梦想。病人似乎“表演他们的梦”，其中所展示的行为反映了梦的内容。RBD的管理涉及有关睡眠环境中安全措施的咨询;在那些有受伤风险的人中，氯硝西泮和/或褪黑素通常是有效的。在这篇文章中，作者提出了一个详细的审查的临床和多导睡眠图的特点，鉴别诊断，诊断标准，管理策略，和病理生理机制的RBD。然后，他们回顾了与神经退行性疾病相关的RBD的文献和机构经验，特别是帕金森病和路易体痴呆。不断发展的数据表明，RBD可能具有临床诊断和病理生理学意义，在孤立和与神经退行性疾病。
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by vivid, often frightening dreams associated with simple or complex motor behavior during REM sleep. Patients appear to "act out their dreams," in which the exhibited behaviors mirror the content of the dreams. Management of RBD involves counseling about safety measures in the sleep environment; in those at risk for injury, clonazepam and/or melatonin is usually effective. In this article, the authors present a detailed review of the clinical and polysomnographic features, differential diagnosis, diagnostic criteria, management strategies, and pathophysiologic mechanisms of RBD. They then review the literature and their institutional experience of RBD associated with neurodegenerative disease, particularly Parkinson's disease and dementia with Lewy bodies. The evolving data suggests that RBD may have clinical diagnostic and pathophysiologic significance in isolation and when associated with neurodegenerative disease.