Molecular evolution of peptide methionine sulfoxide reductases (MsrA and MsrB): On the early development of a mechanism that protects against oxidative damage
Molecular evolution of peptide methionine sulfoxide reductases (MsrA and MsrB): On the early development of a mechanism that protects against oxidative damage
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DOI：
10.1007/s00239-005-0281-2
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发表时间：
2007-01-01
影响因子：
3.9
通讯作者：
Lazcano, Antonio
中科院分区：
文献类型：
--
作者：
Delaye, Luis;Becerra, Arturo;Lazcano, Antonio
甲硫氨酸亚砜还原酶是一种逆转甲硫氨酸残基氧化的酶，已在广泛的物种中被描述。氧化甲硫氨酸的非对映异构体的还原由两种不同的单体甲硫氨酸亚砜还原酶（MsrA和MsrB）催化，并且最好理解为对地球大气中或可能在更局部环境中的高水平氧气的进化反应。这些蛋白质的系统发育分析表明，它们的分布是一个复杂的历史，包括许多旁系和横向基因转移事件的结果。
Methionine sulfoxide reductases, enzymes that reverse the oxidation of methionine residues, have been described in a wide range of species. The reduction of the diastereoisomers of oxidized methionine is catalyzed by two different monomeric methionine sulfoxide reductases (MsrA and MsrB) and is best understood as an evolutionary response to high levels of oxygen either in the Earth's atmosphere or possibly in more localized environments. Phylogenetic analyses of these proteins suggest that their distribution is the outcome of a complex history including many paralogy and lateral gene transfer events.