Computer-controlled drug doses for IV drug self-administration.

Computer-controlled drug doses for IV drug self-administration.
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DOI:
10.1037/a0023037
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发表时间:
2011-04
影响因子:
2.3
通讯作者:
Fivel, Peter A.
Fivel, Peter A.
中科院分区:
医学3区
文献类型:
--
作者:
Fivel, Peter A.

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本报告描述了一种用于静脉药物自我给药研究的计算机控制药物剂量测定的新程序。通过改变单一浓度药物溶液每次输注的持续时间,可以从同一注射器分配五个或更多单位剂量(mg/kg/注射)。该程序的优点包括:(1)无需为每次剂量变化准备新的注射器; (2) IV 导管管路的无菌性破损较少; (3)避免了通过导管线路冲洗与先前药物剂量的混杂效应。该过程准确可靠,可应用于任意持续时间、跨天或数周的多个会话。
This report describes a novel procedure for computer-controlled drug-dose determination for IV drug self-administration studies. By modifying the duration of each infusion of a single concentration of a drug solution, five or more unit doses (mg/kg/inj) can be dispensed from the same syringe. The advantages of this procedure include the following: (1) it is not necessary to prepare a new syringe for each dose change; (2) the sterility of the IV catheter line is broken less often and; (3) the confounding effect of flushing through the catheter line with the previous drug dose is avoided. This procedure is accurate and reliable and can be applied to multiple sessions of any duration across days or weeks.
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