Dietary antioxidants and the aetiology of pancreatic cancer: a cohort study using data from food diaries and biomarkers
Dietary antioxidants and the aetiology of pancreatic cancer: a cohort study using data from food diaries and biomarkers
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DOI：
10.1136/gutjnl-2011-301908
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发表时间：
2013-10-01
期刊：
影响因子：
24.5
通讯作者：
Hart, Andrew R.
中科院分区：
文献类型：
--
作者：
Banim, Paul J. R.;Luben, Robert;Hart, Andrew R.
目的探讨膳食抗氧化剂维生素C和E、硒和锌是否能降低胰腺癌的发生风险，首次采用前瞻性研究中最准确的膳食方法——7天饮食日记法。设计23 ?658名年龄在40-74岁之间的参与者被招募到EPIC-Norfolk研究中，他们完成了为期7天的食物日记，记录了食物、品牌和份量。随后诊断为胰腺癌的患者和3970名对照者的营养摄入量被计算出来，使用的是含有11？000年的食物。测定血清样品中的维生素C。通过摄入四分位数和最低四分位数（Q1）的阈值与三个最高四分位数（Q2-4）的总和来估计发展为胰腺癌的hr。结果在10年内，49名参与者（55%为男性）发展为胰腺癌。那些将所有维生素C、E和硒的最高四分位数组合食用的人风险降低(HR=0.33, 95% CI 0.13至0.84,p
Objective To investigate whether the dietary antioxidants vitamins C and E, selenium and zinc decrease the risk of developing pancreatic cancer, for the first time using 7-day food diaries, the most accurate dietary methodology in prospective work.Design 23?658 participants, aged 40-74years, recruited into the EPIC-Norfolk Study completed 7-day food diaries which recorded foods, brands and portion sizes. Nutrient intakes were calculated in those later diagnosed with pancreatic cancer and in 3970 controls, using a computer program with information on 11?000 foods. Vitamin C was measured in serum samples. The HRs of developing pancreatic cancer were estimated across quartiles of intake and thresholds of the lowest quartile (Q1) against a summation of the three highest (Q2-4).Results Within 10years, 49 participants (55% men), developed pancreatic cancer. Those eating a combination of the highest three quartiles of all of vitamins C and E and selenium had a decreased risk (HR=0.33, 95% CI 0.13 to 0.84, p