What is the fate of diacylglycerol produced at the Golgi apparatus?
What is the fate of diacylglycerol produced at the Golgi apparatus?
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高尔基体产生的二酰甘油的命运如何？
DOI：
10.1016/0968-0004(88)90082-5
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发表时间：
1988
影响因子：
13.8
通讯作者：
Pagano,RE
中科院分区：
文献类型：
--
作者：
Pagano,RE
在本文中，我回顾了我们目前对发生在内质网(ER)和高尔基体中的一些重要的脂质生物合成反应的理解，并提醒人们注意这样一个事实，即如果神经鞘磷脂(SM)合成发生在高尔基体，必须在高尔基体形成大量的二酰甘油(DA G)。由于DA G具有细胞内第二信使L的功能，因此似乎有必要将其在细胞内的浓度保持在较低水平，因此需要一种消除高尔基体中形成的DA G的机制。我提出了几种可能发生这种情况的机制，并强调了其中一些机制对通过内质网-高尔基复合体的膜脂运输的影响。
In this article I review our current understanding of some important lipid biosynthetic reactions taking place in the endoplasmic reticulum (ER) and Golgi apparatus, and call attention to the fact that significant amounts of diacylglycerol (DA G) must be formed at the Golgi apparatus if sphingomyelin (SM) synthesis occurs there. Since DA G functions as an intracellular second messenger l, it seems necessary to keep its concentration within the cell low, and thus a mechanism for eliminating DA G formed at the Golgi apparatus is needed. I suggest several mechanisms by which this could occur, and highlight the implications of some of these mechanisms on membrane lipid traffic through the ER-Golgi complex.