Combined effect of high depressive symptom burden and hypertension on new-onset stroke: evidence from a nationwide prospective cohort study
Combined effect of high depressive symptom burden and hypertension on new-onset stroke: evidence from a nationwide prospective cohort study
复制标题
高抑郁症状负担和高血压对新发卒中的综合影响：来自全国前瞻性队列研究的证据。
DOI：
10.1097/hjh.0000000000002599
复制
发表时间：
2021-01-01
影响因子：
4.9
通讯作者：
Shen, Yueping
中科院分区：
文献类型：
--
作者：
Liu, Siyuan;Qiao, Yanan;Shen, Yueping
**目的**：本研究旨在通过一项全国性前瞻性研究，探究在中国中老年人中，高抑郁症状负担与高血压并存是否会增加中风风险。
**方法**：采用2011 - 2015年中国健康与养老追踪调查（CHARLS）的数据。最终分析纳入了12604名年龄在45岁及以上的中国参与者。运用多变量Cox比例风险回归模型，探究高抑郁症状负担、高血压与新发中风之间的关联。
**结果**：在4年的随访期间，共发生244例中风事件。与无高抑郁症状负担和高血压者相比，仅存在高抑郁症状负担者的校正风险比（95%置信区间）为1.96（1.13 - 3.42），仅患高血压者为2.84（1.77 - 4.57），高抑郁症状负担与高血压并存者为4.38（2.66 - 7.20）。在亚组分析中，高抑郁症状负担与高血压并存者在所有亚组中发生新发中风的风险最高。
**结论**：研究结果表明，在中国中老年人中，高抑郁症状负担与高血压对中风风险具有联合作用。
Objective: The aim of this study was to investigate whether the combination of high depressive symptom burden and hypertension increased the risk of stroke among the middle-aged and elderly Chinese using a nationwide prospective study. Methods: Data from the China Health and Retirement Longitudinal Study (CHARLS) during 2011-2015 were used. A total of 12 604 Chinese participants aged 45 years and older were included for final analysis. Multivariate Cox proportional hazards regression model was used to explore the associations between high depressive symptom burden, hypertension and new-onset stroke. Results: There were 244 stroke events occurred during a 4-year follow-up. Compared with those without high depressive symptom burden and hypertension, the adjusted hazard ratios (95% confidence intervals) were 1.96 (1.13-3.42) for individuals with high depressive symptom burden alone, 2.84 (1.77-4.57) for individuals with hypertension alone and 4.38 (2.66-7.20) for individuals with comorbid high depressive symptom burden and hypertension, respectively. In the subgroup analyses, people with the coexistence of high depressive symptom burden and hypertension had the highest risk of new-onset stroke in all subgroups. Conclusion: Our results suggest a combined effect of high depressive symptom burden and hypertension on stroke risk among the middle-aged and elderly Chinese.