Continuous Theta Burst Stimulation Over the Dorsolateral Prefrontal Cortex and the Pre-SMA Alter Drift Rate and Response Thresholds Respectively During Perceptual Decision-Making
Continuous Theta Burst Stimulation Over the Dorsolateral Prefrontal Cortex and the Pre-SMA Alter Drift Rate and Response Thresholds Respectively During Perceptual Decision-Making
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DOI：
10.1016/j.brs.2016.04.004
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发表时间：
2016-07-01
影响因子：
7.7
通讯作者：
Jahanshahi, Marjan
中科院分区：
文献类型：
--
作者：
Georgiev, Dejan;Rocchi, Lorenzo;Jahanshahi, Marjan
背景：速度与精度的权衡(SAT)指的是在决策过程中速度与精度之间的平衡。SAT通常被用来研究知觉决策任务，如移动圆点任务(MDT)。背外侧前额叶皮质(DLPFC)和前补充运动区(Pre-SMA)被认为是参与控制SAT的两个脑区。目的/假设：本研究验证了DLPFC和Pre-SMA是否在控制SAT中起重要作用。我们假设，在右侧DLPFC上持续的电刺激(CTB)将主要改变证据的积累速度，而SMA前的刺激将影响做出决定的阈值。方法：15名健康志愿者(5名女性，平均年龄30岁，SD=5.40)参与研究。我们在右侧DLPFC上使用了两种版本的MDT和CTBS，前SMA和假刺激。漂移扩散模型与行为数据(反应时和错误率)进行拟合，以计算漂移率、边界分离(阈值)和非决策时间。结果：右侧DLPFC上的CTBS在高(0.35和0.5)的实验中降低了证据积累的速率(即来自扩散模型的漂移率)，但在低一致性试验中没有。SMA前的CTBS改变了对准确度做出决定所需的边界分离/阈值，但对速度试验没有影响。结论：结果首次表明DLPFC和SMA前对SAT的调制都做出了基本但不同的贡献。(C)爱思唯尔公司出版的2016年。
Background: The speed-accuracy trade-off (SAT) refers to the balancing of speed versus accuracy during decision-making. SAT is very commonly investigated with perceptual decision-making tasks such as the moving dots task (MDT). The dorsolateral prefrontal cortex (DLPFC) and the pre-supplementary motor area (pre-SMA) are two brain regions considered to be involved in the control of SAT.Objectives/hypotheses: The study tested whether the DLPFC and the pre-SMA play an essential role in the control of SAT. We hypothesized that continuous theta burst stimulation (cTBS) over the right DLPFC would primarily alter the rate of accumulation of evidence, whereas stimulation of the pre-SMA would influence the threshold for reaching a decision.Methods: Fifteen (5 females; mean age = 30, SD = 5.40) healthy volunteers participated in the study. We used two versions of the MDT and cTBS over the right DLPFC, pre-SMA and sham stimulation. The drift diffusion model was fit to the behavioural data (reaction time and error rate) in order to calculate the drift rate, boundary separation (threshold) and non-decision time.Results: cTBS over the right DLPFC decreased the rate of accumulation of evidence (i.e. the drift rate from the diffusion model) in high (0.35 and 0.5) but not in low coherence trials. cTBS over the pre-SMA changed the boundary separation/threshold required to reach a decision on accuracy, but not on speed trials.Conclusions: The results suggest for the first time that both the DLPFC and the pre-SMA make essential but distinct contributions to the modulation of SAT. (C) 2016 Published by Elsevier Inc.