Morphological dynamics of mitochondria--a special emphasis on cardiac muscle cells.

Morphological dynamics of mitochondria--a special emphasis on cardiac muscle cells.
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DOI:
10.1016/j.yjmcc.2009.02.023
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发表时间:
2009-06
影响因子:
5
通讯作者:
Sheu, Shey-Shing
Sheu, Shey-Shing
中科院分区:
医学2区
文献类型:
--
作者:
Hom, Jennifer;Sheu, Shey-Shing

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线粒体在细胞能量代谢、Ca2+稳态、活性氧生成、细胞凋亡、衰老和发育中起着关键作用。许多最近的出版物表明,这些细胞器的融合和裂变的持续平衡是维持其正常功能的重要因素。因此,线粒体的形式和功能之间存在着密切的相关性。许多参与线粒体融合和裂变的主要蛋白质已经在不同的细胞类型中被发现,包括心脏。然而,线粒体动力学在心脏中的功能作用在很大程度上仍未被探索。在这篇综述中,我们将涵盖线粒体动力学及其生理和病理意义的最新领域,特别强调线粒体动力学在心脏中的实验和理论基础。
Mitochondria play a critical role in cellular energy metabolism, Ca2+ homeostasis, reactive oxygen species generation, apoptosis, aging, and development. Many recent publications have shown that a continuous balance of fusion and fission of these organelles is important in maintaining their proper function. Therefore, there is a steep correlation between the form and function of mitochondria. Many major proteins involved in mitochondrial fusion and fission have been identified in different cell types, including heart. However, the functional role of mitochondrial dynamics in the heart remains, for the most part, unexplored. In this review we will cover the recent field of mitochondrial dynamics and its physiological and pathological implications, with a particular emphasis on the experimental and theoretical basis of mitochondrial dynamics in the heart.
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