Fourier-Transform MS and Closed-Path Multireflection Time-of-Flight MS Using an Electrostatic Linear Ion Trap
Fourier-Transform MS and Closed-Path Multireflection Time-of-Flight MS Using an Electrostatic Linear Ion Trap
复制标题
使用静电线性离子阱的傅里叶变换 MS 和闭路多重反射飞行时间 MS
DOI：
10.1021/acs.analchem.7b02797
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发表时间：
2017
影响因子：
7.4
通讯作者：
McLuckey, Scott A.
中科院分区：
文献类型：
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作者：
Dziekonski, Eric T.;Johnson, Joshua T.;Lee, Kenneth W.;McLuckey, Scott A.
静电线性离子阱（ELIT）已被配置为允许通过傅里叶变换（FT）技术（频率测量）和通过飞行时间（TOF;时间测量）同时采集质谱。在前一种情况下，从ELIT的无场区域中的拾取电极导出的时域图像电荷经由傅立叶变换被转换为频域数据（即，FT-ELIT MS）。在后一种情况下，离子注入ELIT与使用微通道板（MCP）从ELIT释放后离子检测之间的时间差使得能够获得多重反射飞行时间质谱（MR-TOF MS）。ELIT几何结构便于同时采集两种类型的数据，因为检测方案是独立的，并且不相互排斥。这两种MS方法表现出一定程度的互补性。例如，使用MR-TOF方法，分辨率随时间增加得更快，但是在ELIT中执行MR-TOF的闭合路径性质限制了它们/zrange和峰值容量。因此，FT-ELIT MS方法最适合于宽范围应用，而MR-TOF MS可以在"放大"模式下提供优势，其中在短分析时间（10 ms）下的中等分辨率（M/Δ Mfwhm ≤ 10000）是理想的。
An electrostatic linear ion trap (ELIT) has been configured to allow for the simultaneous acquisition of mass spectra via Fourier transform (FT) techniques (frequency measurement) and via time-of-flight (TOF; time measurement). In the former case, the time-domain image charge derived from a pick-up electrode in the field-free region of the ELIT is converted to frequency-domain data via Fourier transformation (i.e., FT-ELIT MS). In the latter case, the time difference between ion injection into the ELIT and ion detection after release from the ELIT using a microchannel plate (MCP) enables the acquisition of multireflection time-of-flight mass spectra (MR-TOF MS). The ELIT geometry facilitates the acquisition of both types of data simultaneously because the detection schemes are independent and do not preclude one another. The two MS approaches exhibit a degree of complementarity. Resolution increases much faster with time with the MR-TOF approach, for example, but the closed-path nature of executing MR-TOF in an ELIT limits both them/zrange and the peak capacity. For this reason, the FT-ELIT MS approach is most appropriate for widem/zrange applications, whereas MR-TOF MS can provide advantages in a “zoom-in” mode in which moderate resolution (M/ΔMfwhm≈ 10000) at short analysis times (10 ms) is desirable.