Profiling nitric oxide metabolites in patients with idiopathic pulmonary arterial hypertension
Profiling nitric oxide metabolites in patients with idiopathic pulmonary arterial hypertension
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特发性肺动脉高压患者的一氧化氮代谢物分析
DOI：
10.1183/13993003.00245-2016
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发表时间：
2016-09
影响因子：
24.3
通讯作者：
Jing ZC
中科院分区：
文献类型：
--
作者：
Zhang R;Wang XJ;Zhang HD;Sun XQ;Zhao QH;Wang L;He J;Jiang X;Liu JM;Jing ZC
完整的一氧化氮（NO）信号对于维持适当的肺血管张力至关重要。肺动脉高压患者一氧化氮的生物利用度降低。本研究旨在探讨一氧化氮血浆代谢产物（NOx）对特发性肺动脉高压（IPAH）患者血流动力学功能障碍和死亡率的影响。在这项前瞻性研究中，共有104名连续的IPAH成年患者在首次诊断时接受了遗传咨询。骨形态发生蛋白受体2型（BMPR2）突变携带者的NOx中位浓度（μmol·L−1）显著低于健康人群，且与非携带者相比，19例IPAH患者的NOx中位浓度（μmol·L−1）进一步降低。NOx浓度降低与平均肺动脉压（mPAP）、肺血管阻力（PVR）和心输出量相关。与较高的NOx基线浓度相比，NOx浓度≤10 μmol·L−1的患者生存期明显较差。在对临床特征、BMPR2突变和血流动力学进行调整后，较低的氮氧化物水平仍会增加死亡风险。IPAH患者血浆NOx水平较低，与mPAP、PVR和生存率呈负相关。血浆NOx可能是一个重要的生物标志物和预后指标，提示一氧化氮合成减少参与了IPAH的发病机制。血浆NOx显著降低，与IPAH患者血流动力学、死亡率和BMPR2突变相关http://ow.ly/vyNO301PNyZ
Intact nitric oxide (NO) signalling is critical to maintaining appropriate pulmonary vascular tone. NO bioavailability is reduced in patients with pulmonary arterial hypertension. This study aimed to examine the impact of NO plasma metabolites (NOx) relative to haemodynamic dysfunction and mortality in patients with idiopathic pulmonary arterial hypertension (IPAH). A total of 104 consecutive adult IPAH patients who had undergone genetic counselling when first diagnosed were enrolled in this prospective study. The median concentration of NOx (μmol·L−1) was significantly lower in IPAH patients compared with healthy subjects, and was decreased further in 19 carriers of the bone morphogenetic protein-receptor type-2 (BMPR2) mutation compared to non-carriers. Reduced concentrations of NOx were correlated with mean pulmonary arterial pressure (mPAP), pulmonary vascular resistance (PVR) and cardiac output. Compared with higher baseline NOx concentrations, patients with a NOx concentration of ≤10 μmol·L−1 had a markedly worse survival. After adjustment for clinical features, a BMPR2 mutation and haemodynamics, a lower NOx level remained an increased risk of mortality. Patients with IPAH had lower levels of plasma NOx, which correlated inversely with mPAP, PVR and survival. Plasma NOx may be an important biomarker and prognostic indicator, suggesting that reduced NO synthesis contributes to the pathogenesis of IPAH. Plasma NOx was significantly lower, and related to haemodynamics, mortality and BMPR2 mutation in patients with IPAH http://ow.ly/vyNO301PNyZ
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影响因子：
82.9
作者：
Hunter, CJ;Dejam, A;Gladwin, MT
通讯作者：
Gladwin, MT
影响因子：
0.7
作者：
M. Gorenflo;C. Zheng;A. Pöge;M. Bettendorf;E. Werle;W. Fiehn;H. Ulmer
通讯作者：
M. Gorenflo;C. Zheng;A. Pöge;M. Bettendorf;E. Werle;W. Fiehn;H. Ulmer
DOI：
10.1164/ajrccm.163.4.2007116
发表时间：
2001-03-01
影响因子：
24.7
作者：
Nagaya, N;Uematsu, M;Miyatake, K
通讯作者：
Miyatake, K
影响因子：
37.8
作者：
N. Nagaya;T. Nishikimi;M. Uematsu;T. Satoh;S. Kyotani;F. Sakamaki;M. Kakishita;K. Fukushima;
通讯作者：
N. Nagaya;T. Nishikimi;M. Uematsu;T. Satoh;S. Kyotani;F. Sakamaki;M. Kakishita;K. Fukushima;
影响因子：
37.8
作者：
Elliott, C. Gregory;Glissmeyer, Eric W.;Ward, Kenneth
通讯作者：
Ward, Kenneth