Hormonal Effects of Smoking— I: Effects on Plasma Renin Activity
Hormonal Effects of Smoking— I: Effects on Plasma Renin Activity
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吸烟对荷尔蒙的影响——I：对血浆肾素活性的影响
DOI：
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发表时间：
1986
影响因子：
3.1
通讯作者：
D. Rovner
中科院分区：
文献类型：
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作者：
V. Gossain;N. K. Sherma;L. Srivastava;A. Michelakis;D. Rovner
人们普遍认为，吸烟与患冠状动脉疾病的风险增加有关。由于已经表明血浆肾素活性(PRA)升高可能是心血管疾病的危险因素，因此对吸烟者和非吸烟者的PRA进行了测量。在基础条件下、静脉注射速尿和短暂吸烟后测定PRA。此外，还在体外观察了尼古丁对肾素分泌的影响。在两组中，吸烟与脉率和收缩压显著增加有关，但对舒张压没有显著影响。基础PRA在吸烟者中相似，并且在两组中都不受吸烟的显著影响。静脉注射速尿后PRA显著升高，但两组间无显著差异。大鼠肾脏切片与尼古丁孵育也没有导致肾素分泌增加。这些发现证实了吸烟对心血管系统的影响，但在体内和体外实验中都没有观察到吸烟对PRA的显著影响。这些发现表明，与吸烟相关的冠状动脉疾病风险的增加并不是由PRA增加所介导的
It is generally recognized that smoking is associated with an increased risk for the development of coronary artery disease. Since it has been suggested that increased plasma renin activity (PRA) may be a risk factor for cardiovascular disease, PRA was measured in a group of smokers and nonsmokers. PRA was measured under basal conditions, following intravenous (IV) furosemide administration and after a short burst of smoking. In addition, the effect of nicotine on renin secretion was evaluated in vitro. Smoking was associated with a significant increase in pulse rate and systolic blood pressure, but no significant change in diastolic blood pressure, in both groups. Basal PRA was similar among smokers and was not significantly influenced by smoking in either group. PRA increased significantly following IV administration of furosemide, but there was no significant difference between the two groups. Incubation of rat kidney slices with nicotine also did not result in increased renin secretion. These findings confirm that smoking affects the cardiovascular system, but no significant effect of smoking on PRA was observed both in vivo and in vitro experiments. These findings suggest that the increased risk for the development of coronary artery disease associated with smoking is not mediated by increased PRA