Time elapsed between Zika and dengue virus infections affects antibody and T cell responses
Time elapsed between Zika and dengue virus infections affects antibody and T cell responses
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DOI：
10.1038/s41467-019-12295-2
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发表时间：
2019-04
影响因子：
16.6
通讯作者：
Erick X Pérez-Guzmán;Petraleigh Pantoja;Crisanta Serrano-Collazo;Mariah A. Hassert;A. Ortiz-Rosa;I. Rodríguez;L. Giavedoni;V. Hodara;L. Parodi;Lorna Cruz;T. Arana;L. White;Melween I. Martínez;D. Weiskopf;J. Brien;A. D. de Silva;Amelia K. Pinto;C. Sariol
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文献类型：
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作者：
Erick X Pérez-Guzmán;Petraleigh Pantoja;Crisanta Serrano-Collazo;Mariah A. Hassert;A. Ortiz-Rosa;I. Rodríguez;L. Giavedoni;V. Hodara;L. Parodi;Lorna Cruz;T. Arana;L. White;Melween I. Martínez;D. Weiskopf;J. Brien;A. D. de Silva;Amelia K. Pinto;C. Sariol
寨卡病毒（ZIKV）和登革病毒（DENV）在世界许多地区共同流行，但ZIKV感染对随后的DENV感染的影响尚不清楚。在这里，我们在恒河猴中显示，ZIKV感染后经过的时间影响对DENV感染的免疫应答。我们表明，先前的ZIKV暴露增加了针对DENV的抗体和T细胞应答的幅度。ZIKV和随后的DENV感染之间的时间间隔进一步影响免疫应答。ZIKV感染后10个月的中期恢复期导致比2个月的短时期更高和更持久的针对DENV感染的抗体和T细胞应答。相反，先前的ZIKV感染不影响DENV病毒血症或促炎状态。总的来说，我们没有发现ZIKV免疫在随后的DENV感染中的有害影响的证据。这支持ZIKV疫苗的实施，也可以提高对未来DENV流行病的免疫力。
Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV exposure increases the magnitude of the antibody and T cell responses against DENV. The time interval between ZIKV and subsequent DENV infection further affects the immune response. A mid-convalescent period of 10 months after ZIKV infection results in higher and more durable antibody and T cell responses to DENV infection than a short period of 2 months. In contrast, previous ZIKV infection does not affect DENV viremia or pro-inflammatory status. Collectively, we find no evidence of a detrimental effect of ZIKV immunity in a subsequent DENV infection. This supports the implementation of ZIKV vaccines that could also boost immunity against future DENV epidemics.