The American Cancer Society cancer prevention study II nutrition cohort - Rationale, study design, and baseline characteristics
The American Cancer Society cancer prevention study II nutrition cohort - Rationale, study design, and baseline characteristics
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DOI：
10.1002/cncr.101970.abs
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发表时间：
2002-05-01
期刊：
影响因子：
6.2
通讯作者：
Thun, MJ
中科院分区：
文献类型：
--
作者：
Calle, EE;Rodriguez, C;Thun, MJ
背景大规模的前瞻性队列研究在发现导致人群癌症风险变化的因素方面发挥了关键作用。美国癌症协会（ACS）的流行病学家和志愿者是最早建立这种队列的人之一，从20世纪50年代初开始一直持续到现在，这些ACS队列在流行病学研究的许多领域都做出了里程碑式的贡献。癌症预防研究11营养队列成立于1992年，旨在调查饮食和其他生活方式因素与暴露和癌症风险，死亡率和生存率之间的关系。该队列包括超过84，000名男性和97，000名女性，他们在1992年完成了邮寄问卷。每隔一年向存活的队列成员发送新的问卷，以更新暴露信息并确定癌症的新发生率; 1997年和1999年的随访问卷的答复率达到90%。报告的癌症通过医疗记录、登记联系或死亡证明进行核实。对所有癌症发病病例和所有死亡原因积极跟踪队列。通过ACS国家和部门工作人员，志愿者和美国外科医生学院之间的合作努力，从40，000名队列成员的亚组中收集血液样本，并储存在中央储存库中，用于未来调查饮食，激素，遗传和其他因素以及癌症风险。另外5万名队列成员的口腔细胞DNA样本的采集目前正在进行中，将于2002年完成。这一新的男性和女性队列有望对癌症发生率，死亡率和生存率的研究特别有价值，因为它们与肥胖和体重变化，生活中各个阶段的体力活动，维生素补充剂的使用，外源性激素的使用，其他药物（如阿司匹林和非甾体抗炎药）和癌症筛查方式有关。(C)2002年美国癌症协会。
BACKGROUND. Large-scale, prospective cohort studies have played a critical role in discovering factors that contribute to variability in cancer risk in human populations. Epidemiologists and volunteers at the American Cancer Society (ACS) were among the first to establish such cohorts, beginning in the early 1950s and continuing through the present, and these ACS cohorts have made landmark contributions in many areas of epidemiologic research.METHODS AND RESULTS. The Cancer Prevention Study 11 Nutrition Cohort was established in 1992 and was designed to investigate the relation between diet and other lifestyle factors and exposures and the risk of cancer, mortality, and survival. The cohort includes over 84,000 men and 97,000 women who completed a mailed questionnaire in 1992. New questionnaires are sent to surviving cohort members every other year to update exposure information and to ascertain new occurrences of cancer; a 90% response rate was achieved for follow-up questionnaires in 1997 and 1999. Reported cancers are verified through medical records, registry linkage, or death certificates. The cohort is followed actively for all cases of incident cancer and for all causes of death. Through a collaborative effort among ACS national and division staff, volunteers, and the American College of Surgeons, blood samples were collected from a subgroup of 40,000 cohort members and are in storage at a central repository for future investigation of dietary, hormonal, genetic, and other factors and cancer risk. Collection of DNA samples from buccal cells in an additional 50,000 cohort members is underway currently and will be completed in 2002.CONCLUSIONS. This new cohort of both men and women promises to be particularly valuable for the study of cancer occurrence, mortality, and survival as they relate to obesity and weight change, physical activity at various points in life, vitamin supplement use, exogenous hormone use, other medications (such as aspirin and nonsteroidal anti-inflammatory drugs) and cancer screening modalities. (C) 2002 American Cancer Society.