Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action
Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action
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DOI：
10.1126/scitranslmed.aaf9246
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发表时间：
2016-10-26
影响因子：
17.1
通讯作者：
de Bono, Johann
中科院分区：
文献类型：
--
作者：
Pommier, Yves;O'Connor, Mark J.;de Bono, Johann
聚（ADP-核糖）聚合酶（PARP）抑制剂是第一个被批准用于癌症治疗的 DNA 损伤反应靶向药物。在这里，我们重点关注其通过 PARP“捕获”作用的分子机制，以及这对临床单药治疗和与化疗药物联合治疗的意义。
Poly(ADP-ribose) polymerase (PARP) inhibitors are the first DNA damage response targeted agents approved for cancer therapy. Here, we focus on their molecular mechanism of action by PARP "trapping" and what this means for both clinical monotherapy and combination with chemotherapeutic agents.