The Bysl gene product, bystin, is essential for survival of mouse embryos
The Bysl gene product, bystin, is essential for survival of mouse embryos
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DOI：
10.1016/j.febslet.2006.09.072
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发表时间：
2006-11-13
期刊：
影响因子：
3.5
通讯作者：
Fukuda, Michiko N.
中科院分区：
文献类型：
--
作者：
Aoki, Rui;Suzuki, Nao;Fukuda, Michiko N.
人bystin是一种细胞质蛋白，与滋养蛋白直接结合，滋养蛋白是一种细胞粘附分子，可能参与人胚胎着床。目前的研究表明，bystin在小鼠子宫腔上皮和腺上皮在围着床期的表达。在受精胚胎中，bystin直到囊胚期才被检测到。Bystin的表达开始于孵化期，并在扩张的囊胚中增加。然而，bystin在着床过程中明显从囊胚中消失。植入后，bystin重新出现在上胚层。靶向破坏小鼠bystin基因，Bysl，导致胚胎死亡后不久植入，表明bystin是小鼠胚胎的生存所必需的。(c)2006年欧洲生物化学学会联合会。Elsevier B.V.出版，保留所有权利。
Human bystin is a cytoplasmic protein directly binding to trophinin, a cell adhesion molecule potentially involved in human embryo implantation. The present study shows that bystin is expressed in luminal and glandular epithelia in the mouse uterus at peri-implantation stages. In fertilized embryos, bystin was not seen until blastocyst stage. Bystin expression started during hatching and increased in expanded blastocyst. However, bystin apparently disappeared from the blastocyst during implantation. After implantation bystin re-appeared in the epiblast. Targeted disruption of the mouse bystin gene, Bysl, resulted in embryonic lethality shortly after implantation, indicating that bystin is essential for survival of mouse embryos. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.