Three-DimensionalPrinted Model Fabrication and Effectiveness Evaluation in Fetuses With Congenital Heart Disease or With a Normal Heart
Three-DimensionalPrinted Model Fabrication and Effectiveness Evaluation in Fetuses With Congenital Heart Disease or With a Normal Heart
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先天性心脏病或心脏正常胎儿的三维打印模型制作和有效性评估
DOI：
10.1002/jum.15366
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发表时间：
2020-06-20
影响因子：
2.3
通讯作者：
Zhou, Qing
中科院分区：
文献类型：
--
作者：
Huang, Jia;Shi, Hua;Zhou, Qing
目的探讨基于时空图像相关（STIC）体绘制数据三维打印正常和异常胎儿心脏的技术可行性和准确性。方法收集15例正常胎儿和15例心脏畸形胎儿的时空相关容积图像，（Materialise NV，Leuven，Belgium）用于后处理体积数据以获得胎儿心脏和大血管形态特征的3D数字模型，并将文件输出到3D打印机以打印胎儿心脏和大血管的3D模型。通过结合超声心动图或尸检结果显示模型的3D解剖结构，定性评价3D打印模型的效果准确性;通过比较模型和超声心动图的测量数据，定量评价3D打印模型的尺寸准确性。结果30例胎儿的STIC容积数据均成功地进行了再处理并打印出来，能直观地显示正常和异常病理状态下胎儿心腔的形态特征和大血管的走行情况。3D数字模型、3D打印模型和常规超声心动图图像之间的所有心脏大小参数均无显著差异（均P> 0.05）。此外，两种方法之间的尺寸参数一致性良好，所有数据点均在一致性范围内。结论以STIC容积图像为数据源进行胎儿心脏三维打印是可行的，三维打印模型能全面、准确地显示心脏的异常解剖结构。
Objectives The purpose of this study was to investigate the technical feasibility and accuracy of applying 3-dimensional (3D) printing of normal and abnormal fetal hearts based on spatiotemporal image correlation (STIC) volume-rendered data. Methods Spatiotemporal image correlation volume images of 15 healthy fetuses and 15 fetuses with cardiac abnormalities were collected, and Mimics software (Materialise NV, Leuven, Belgium) was used to postprocess the volume data to obtain a 3D digital model of fetal heart and large blood vessel morphologic characteristics and to output the file to a 3D printer for printing the 3D model of the fetal heart and large blood vessels. The effect accuracy of the 3D printed model was qualitatively evaluated by showing the 3D anatomic structure of the model combined with echocardiographic or autopsy results, and the dimensional accuracy of the 3D printed model was quantitatively evaluated by comparing the measured data of the model and echocardiography. Results In all 30 fetuses, STIC volume data of the fetal heart were successfully reprocessed and printed out, which could visually display the morphologic characteristics of the fetal heart chamber and passage of the great vessels under normal and abnormal pathologic conditions. No significant differences in all of the heart size parameters were found between the 3D digital model, 3D printed model, and routine echocardiographic images (allP > .05). Moreover, the size parameters were concordant well between the methods, and all of the data points fell within the limits of agreement. Conclusions It is feasible to 3D print the fetal heart using STIC volumetric images as the data source, and the 3D printed model can fully and accurately display abnormal anatomic structures of the heart.