High uric acid level associated with increased arterial stiffness in apparently healthy women
High uric acid level associated with increased arterial stiffness in apparently healthy women
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DOI：
10.1016/j.atherosclerosis.2014.07.024
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发表时间：
2014-10-01
期刊：
影响因子：
5.3
通讯作者：
Chang, Chih-Jen
中科院分区：
文献类型：
--
作者：
Fang, Jo-I;Wu, Jin-Shang;Chang, Chih-Jen
目的：血尿酸水平升高被认为是心血管疾病的危险因素，并被发现与动脉僵硬增加有关。虽然以前的研究调查了血尿酸和动脉僵硬之间的关系，但大多数研究都没有排除混杂因素，如高血压、糖尿病、血脂异常和高尿酸血症的病史或药物。这项研究的目的是在一个明显健康的人群中探索尿酸与动脉僵硬的关系。方法：这项横断面研究在2006年10月至2009年8月期间招募了7025名参与者。最终共有5150名看似健康的受试者入选。用臂踝脉搏波速度(BaPWV)测量动脉硬度。男性(Q1：59.5~333.1，Q2：333.2~380.7，Q3：380.8~428.3，Q4：428.4~701.9 Mol/L)和女性(Q1：113.0~236.4，Q2：236.5~273.6，Q3：273.7~315.2，Q4：315.3~585.0 mm ol/L)尿酸水平差异有统计学意义。方差分析显示，血尿酸Q3和Q4的女性baPWV水平较高。多因素Logistic回归分析显示，女性尿酸Q4(OR=1.53，95%CI=1.04~2.26)与baPWV升高呈正相关，而男性与尿酸呈正相关。此外，年龄和高血压也是两种性别动脉僵硬增加的独立关联因素。结论：在表面健康的女性中，血尿酸或更高的正常值与动脉僵硬的风险更大相关。然而，在男性中，高尿酸血症与动脉僵硬增加的关系并不显著。(C)2014爱思唯尔爱尔兰有限公司。保留所有权利。
Objectives: Increased serum uric acid level is regarded as a risk factor for cardiovascular disease, and found to be associated with increased arterial stiffness. While previous studies investigated the relationship between serum uric acid and arterial stiffness, most did not exclude the confounding factors, such as history or medications of hypertension, diabetes, dyslipidemia and hyperuricemia. The aim of this study was to explore the association of uric acid with arterial stiffness in an apparently healthy population.Methods: This cross-sectional study enrolled 7025 participants during health examinations from October 2006 to August 2009. A total of 5150 apparently healthy subjects were enrolled in the final analysis. Arterial stiffness was measured by brachial-ankle pulse wave velocity (baPWV). Uric acid was divided into quartiles in men (Q1: 59.5-333.1, Q2: 333.2-380.7, Q3: 380.8-428.3, Q4: 428.4-701.9 mu mol/L) and women (Q1: 113.0-236.4, Q2: 236.5-273.6, Q3: 273.7-315.2, Q4: 315.3-585.0 mmol/L).Results: Uric acid level was significantly different between women with and without increased arterial stiffness, but not in men. ANCOVA showed that women with Q3 and Q4 of serum uric acid had greater baPWV level. In multiple logistic regression analysis, Q4 (OR = 1.53, 95% CI = 1.04-2.26) of uric acid was positively associated with increased baPWV in women, but not in men. In addition, age and high blood pressure were also independently associated factors of increased arterial stiffness for both genders.Conclusion: In apparently healthy women, high-normal serum uric acid or greater was associated with greater risk of arterial stiffness. However, the relationship between hyperuricemia and increased arterial stiffness was not significant in men. (C) 2014 Elsevier Ireland Ltd. All rights reserved.