Frequency of food-dependent, exercise-induced anaphylaxis in Japanese junior-high-school students
Frequency of food-dependent, exercise-induced anaphylaxis in Japanese junior-high-school students
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DOI：
10.1067/mai.2001.119914
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发表时间：
2001-12-01
影响因子：
14.2
通讯作者：
Yokota, S
中科院分区：
文献类型：
--
作者：
Aihara, Y;Takahashi, Y;Yokota, S
背景：食物依赖性运动诱发过敏反应（FEIAn）属于身体过敏。FEIAn的病理生理学仍然未知，FEIAn在一般人群中的发生率也是未知的。目的：我们试图研究FEIAn的流行病学，特别是其在日本横滨市初中学生中的发生率。方法：向横滨市所有145名公立初中护士发送了一份问卷，询问FEIAn在学校学生中的发生情况。结果：132名初中护士回答了问卷，并在76，229名初中学生中报告了13例FEIA病例（11名男孩和2名女孩）。此外，24（12名男孩和12名女孩）的受试者与运动诱发过敏反应（ElAn）的检测。从本次调查来看，FEIA在该人群中的频率为0.017%，男孩的频率显著高于女孩（P <0.05）。ElAn阳性率为0.031%，性别间无差异。只有三分之一的初中护士对FEIA有所了解。我们还进行了激发试验后，从学生和家长知情同意的13例FEIAn，并能够确认diagnosis.Conclusion：这项研究表明，FEIAn和ElAn是比较罕见的疾病初中学生在横滨。为了避免严重的后果，我们认为不仅医生而且学校护士和体育教师都必须意识到这些疾病。
Background: Food-dependent, exercise-induced anaphylaxis (FEIAn) is classified among the physical allergies. The pathophysiology of FEIAn remains unknown, as does the frequency of FEIAn in the general population.Objective: We sought to study the epidemiology of FEIAn, especially its frequency in junior-high-school students in Yokohama, Japan.Methods: A questionnaire asking about the occurrence of FEIAn in school students was sent to all 145 public junior-high-school nurses in Yokohama.Results: One hundred thirty-two junior-high-school nurses responded to the questionnaire, and 13 (11 boys and 2 girls) cases of FEIAn among 76,229 junior-high-school students were reported. In addition, 24 (12 boys and 12 girls) subjects with exercise-induced anaphylaxis (ElAn) were detected. From this survey, the frequency of FEIAn was 0.017% in this population, and its frequency was significantly higher in boys than in girls (P < .05). The frequency of ElAn was 0.031%, and there was no difference according to sex. Only one third of junior-high-school nurses had any knowledge of FEIAn. We also performed provocation tests in 5 of the 13 cases with FEIAn after obtaining informed consent from the students and their parents and were able to confirm the diagnosis.Conclusion: This study showed that FEIAn and ElAn are relatively rare diseases among junior-high-school students in Yokohama. To avoid serious outcomes, we believe it is important that not only physicians but also school nurses and teachers of physical education be aware of these diseases.