FREDERICAMYCIN-A, A NEW ANTI-TUMOR ANTIBIOTIC .1. PRODUCTION, ISOLATION AND PHYSICOCHEMICAL PROPERTIES
FREDERICAMYCIN-A, A NEW ANTI-TUMOR ANTIBIOTIC .1. PRODUCTION, ISOLATION AND PHYSICOCHEMICAL PROPERTIES
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DOI：
10.7164/antibiotics.34.1389
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发表时间：
1981-01-01
影响因子：
3.3
通讯作者：
WHITE, RJ
中科院分区：
文献类型：
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作者：
PANDEY, RC;TOUSSAINT, MW;WHITE, RJ
从灰色链霉菌（Streptomycesgriseus，FCRC-48）中分离得到一种新的抗肿瘤抗生素fredericamycinA（FCRC-A48，NSC-305263）。根据其独特的紫外-可见光谱、红外光谱、质子和13 C核磁共振谱和质谱，判断其为一种新型酸碱指示剂类型的化合物。本文介绍了它的生产、分离和理化性质。本文还介绍了其中两个次要组分fredericamycin B和fredericamycin C的分离、紫外-可见光谱和部分生物学性质。
A new antitumor antibiotic, fredericamycin A (FCRC-A48, NSC-305263), was isolated from a strain of Streptomyces griseus (FCRC-48). Based on its unique UV-visible spectrum, IR spectrum, proton and 13C NMR spectra and mass spectra, it is judged to be a novel acid-base indicator type of compound. Its production, isolation and physicochemical properties are discussed. The isolation, UV-visible spectrum and some biological properties of 2 minor components, fredericamycin B and fredericamycin C, are also described.