Role and Mechanism of Gut Microbiota in Human Disease.
Role and Mechanism of Gut Microbiota in Human Disease.
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肠道微生物群在人类疾病中的作用及机制
DOI：
10.3389/fcimb.2021.625913
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发表时间：
2021
影响因子：
5.7
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Chen Y;Zhou J;Wang L
人体肠道微生物群是一个巨大的微生物群落，在人类生活中发挥着不可替代的作用。随着研究的深入，肠道菌群对人类疾病的影响逐渐被挖掘出来。肠道微生物区系失调对人体健康有不良影响，会导致多种慢性病。转基因对人类疾病的潜在作用机制极其复杂。本文综述了GM对神经退行性疾病、心血管疾病、代谢性疾病和胃肠道疾病的调控及其作用机制，为疾病的防治提供了一个潜在的靶点。
The human gut microbiome is a huge microbial community that plays an irreplaceable role in human life. With the further development of research, the influence of intestinal flora on human diseases has been gradually excavated. Gut microbiota (GM) dysbiosis has adverse health effects on the human body that will lead to a variety of chronic diseases. The underlying mechanisms of GM on human diseases are incredibly complicated. This review focuses on the regulation and mechanism of GM on neurodegenerative diseases, cardiovascular diseases, metabolic diseases and gastrointestinal diseases, thus providing a potential target for the prevention and treatment of disease.