Palladium-Catalyzed Chemo- and Enantioselective C-O Bond Cleavage of α-Acyloxy Ketones by Hydrogenolysis
Palladium-Catalyzed Chemo- and Enantioselective C-O Bond Cleavage of α-Acyloxy Ketones by Hydrogenolysis
复制标题
钯催化氢解作用对 α-酰氧基酮进行化学和对映选择性 C-O 键断裂
DOI：
10.1002/anie.201603590
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发表时间：
2016-07-11
影响因子：
16.6
通讯作者：
Zhang, Wanbin
中科院分区：
文献类型：
--
作者：
Chen, Jianzhong;Zhang, Zhenfeng;Zhang, Wanbin
通过高效的钯催化氢解反应（S/C= 6000，迄今为止催化效率最高），首次实现了α-酰氧基酮酯烷基侧链的化学选择性C-O键断裂。此外，首次发展了对映选择性氢解动力学拆分α-酰氧基酮的方法，产率高达99%ee。
A chemoselective C-O bond cleavage of the ester alkyl side-chain of alpha-acyloxy ketones was realized for the first time by a highly efficient palladium-catalyzed hydrogenolysis (S/C= 6000, the highest catalytic efficiency by far). Furthermore, a kinetic resolution of alpha-acyloxy ketones was first developed by enantioselective hydrogenolysis with good yields and up to 99% ee.