Increased urinary excretion of biopyrrins, oxidative metabolites of bilirubin, in patients with schizophrenia
Increased urinary excretion of biopyrrins, oxidative metabolites of bilirubin, in patients with schizophrenia
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DOI：
10.1016/j.psychres.2006.04.009
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发表时间：
2007-10
影响因子：
11.3
通讯作者：
Rei Yasukawa;T. Miyaoka;H. Yasuda;M. Hayashida;T. Inagaki;Jun Horiguch
中科院分区：
文献类型：
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作者：
Rei Yasukawa;T. Miyaoka;H. Yasuda;M. Hayashida;T. Inagaki;Jun Horiguch
在心理应激期间，会产生过量的自由基，它们在病理生理过程中发挥着重要作用。胆红素氧化代谢物，生物吡喃，是从胆红素产生的这种清除自由基的作用的结果。我们调查了精神分裂症患者在精神状态期间尿生物吡喃的排泄是否发生了变化。用抗胆红素抗体酶联免疫吸附试验测定了15例精神分裂症患者和100例年龄匹配的健康人尿中Biopyrrin的浓度。分别于入院时(急性期)、入院后1个月(亚急性期)、出院时(缓解期)采集尿样。精神分裂症患者入院时尿生物吡喃浓度显著高于对照组。对治疗的反应与生物吡喃浓度的显著降低有关。此外，亚急性期和缓解期精神分裂症患者的尿生物吡喃浓度仍显著高于对照组。这些结果表明，精神分裂症患者尿液中的生物吡喃增加，并且随着精神状态的恢复而减少。提示尿生物吡喃水平可作为临床上连续监测精神疾病状态的一个可能指标。
During periods of psychological stress, excess amounts of free radicals are produced, and they play an important role in the pathophysiological process. Bilirubin oxidative metabolites, biopyrrins, are generated from bilirubin as a result of this scavenging action against free radicals. We investigated whether the urinary excretion of biopyrrin is altered during the psychotic state in patients with schizophrenia. Biopyrrin concentrations in urine of 15 patients with schizophrenia and 100 age-matched healthy subjects were measured by enzyme-linked immunosorbent assay with an anti-bilirubin antibody. Urine samples were obtained from the patients on first admission (acute state), 1 month after admission (sub-acute state), and on discharge (remission state). Urinary concentrations of biopyrrins in patients with schizophrenia on admission were significantly higher than those in the controls. Response to treatment was associated with a significant decrease in the concentrations of biopyrrins. Moreover, urinary concentrations of biopyrrins were still significantly higher in patients with schizophrenia in the sub-acute and remission states than in the controls. These results demonstrated an increase in urinary biopyrrins in patients with schizophrenia and a decrease with recovery from the psychotic state. These findings indicate that the urinary biopyrrin level is a possible indicator that can be useful in the continuous monitoring of psychotic states in clinical practice.