From rafts to crafts:: membrane asymmetry in moving cells
From rafts to crafts:: membrane asymmetry in moving cells
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DOI：
10.1016/s1471-4906(03)00137-6
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发表时间：
2003-06-01
影响因子：
16.8
通讯作者：
Martínez, C
中科院分区：
文献类型：
--
作者：
Mañes, S;Lacalle, RA;Martínez, C
许多重要的生物事件，包括白细胞介导的免疫反应、伤口修复、轴突引导和发育模式，都涉及细胞朝着定向信号持续运动，这一过程称为趋化性。建立功能和空间细胞极性是此响应的绝对要求。我们认为，在细胞迁移过程中，特定膜微域（称为筏）的重新分布是实现极性的关键步骤。一方面，将分子划分成筏可能有助于将蛋白质定位在移动细胞的前部或后部，另一方面，筏可能充当局部激活和协调参与细胞迁移的信号通路的平台。
Many important biological events, including the leukocyte-mediated immune response, wound repair, axon guidance and developmental patterning, involve persistent cell movement towards a directional signal, a process termed chemotaxis. Establishment of functional and spatial cell polarity is an absolute requirement for this response. We propose that redistribution of specific membrane microdomains, termed rafts, during cell migration is a pivotal step in achieving polarity. On the one hand, partitioning of molecules into rafts might help to localize proteins at the front or the rear of moving cells, and on the other hand, rafts might function as platforms for local activation and coordination of the signaling pathways involved in cell migration.