Long-term potentiation and memory.
Long-term potentiation and memory.
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DOI：
10.1007/978-1-4899-6778-7_6
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
T. Teyler
中科院分区：
文献类型：
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作者：
T. Teyler
长时程增强（LTP）是哺乳动物脑内单突触连接处突触效能的一种持久变化。LTP最早出现在海马、CAI区和齿状回。LTP和海马体之间的联系已经很好地建立起来，并表明LTP在学习和记忆中的作用，正如海马体中广泛假设的那样。LTP被认为是大脑长期信息存储（记忆）的神经基础的潜在候选者。LTP的建立需要传入纤维的强直刺激，并且通常涉及突触后群体反应的加倍。LTP在边缘前脑，特别是海马体中表现得最好，在那里它被证明可以持续数天到数周。
Long-term potentiation (LTP) is an enduring change in synaptic efficacy at monosynaptic junctions in the mammalian brain. LTP was first observed in the hippocampus, in area CAI and the dentate gyrus. The link between LTP and hippocampus is well established and suggests a role for LTP in learning and memory, as is widely hypothesized for the hippocampus. LTP is considered a potential candidate for the neural basis of long-term information storage (memory) in the brain. The establishment of LTP requires tetanic stimulation of afferent fibers and typically involves a doubling of the postsynaptic population response. LTP is best represented in the limbic forebrain, particularly hippocampus, where it has been shown to endure for periods ranging from days to weeks.