Viral dynamics of primary HIV-1 infection in Senegal, West Africa.
Viral dynamics of primary HIV-1 infection in Senegal, West Africa.
复制标题
西非塞内加尔原发性 HIV-1 感染的病毒动态。
DOI：
10.1086/429409
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Kanki,Phyllis
中科院分区：
文献类型：
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作者：
Sarr,AbdoulayeDieng;Eisen,Geoffrey;Guèye-Ndiaye,Aissatou;Mullins,Christopher;Traoré,Ibrahima;Dia,MamadouCiré;Sankalé,Jean-Louis;Faye,Diegane;Mboup,Souleymane;Kanki,Phyllis
背景很少有研究涉及撒哈拉以南非洲地区的人类免疫缺陷病毒(HIV)1型感染，那里的流行以异性特征为主，由不同的亚型引起。方法每3个月对752名HIV阴性、感染高危的塞内加尔妇女进行一次HIV急性/早期感染监测，共发现26例感染者，其中HIV-1感染者23例，HIV-2感染者3例，HIV-1发病率为3.23例/人-年。结果所有受试者感染早期病毒载量为4.13±0.66log10拷贝/毫升，早期后病毒载量总体下降0.22log10拷贝/毫升，感染12个月后病毒载量达到设定值。在感染的早期阶段，大多数受试者的病毒载量相对较低。感染HIV-1CRF02_AG的妇女在感染早期的平均病毒载量(平均值±SD)为4.45±0.60log10拷贝/毫升，显著高于未感染HIV-1CRF02_AG的妇女(平均值为3.78±0.46)(P=0.008)。没有一名受试者报告的症状与原发HIV-1感染的症状一致结论我们在塞内加尔妇女中的发现不同于已描述的原发HIV-1感染。有必要对非B亚型的原发感染进行进一步的调查，以更好地区分它们与B亚型的原发感染的区别
BackgroundFew studies have addressed primary human immunodeficiency virus (HIV) type 1 infection in sub-Saharan Africa, where the epidemic is of a predominantly heterosexual character and is caused by different subtypes. The present study examines the dynamics of viral replication in subjects infected with various HIV-1 subtypesMethodsSeven hundred fifty-two HIV-negative Senegalese women at high risk for infection were monitored every 3 months for acute/early HIV infection; 26 infections were identified (23 HIV-1 and 3 HIV-2), with an HIV-1 incidence rate of 3.23 cases/person-years observation. Multiple viral-load measurements were taken for all seroconvertersResultsThe mean ± standard deviation viral load for all subjects during the early stage of infection was 4.13±0.66 log10copies/mL, with an overall decrease of 0.22 log10copies/mL after the early stage; the viral set point was reached after 12 months of infection. Most subjects had relatively low viral loads during the early stage of infection. HIV-1 CRF02_AG–infected women had a significantly higher mean viral load during the early stage of infection (mean ± SD, 4.45±0.60 log10copies/mL) than did non–HIV-1 CRF02_AG–infected women (mean ± SD, 3.78±0.46 log10copies/mL) (P=.008). None of the subjects reported symptoms consistent with primary HIV-1 infectionConclusionOur findings in Senegalese women differ from what have been described for primary HIV-1 infection. Further investigations of primary infections with non-B subtypes are warranted, to better characterize their differences with primary infections with subtype B