Modulation of epithelial cell adhesion in gastrointestinal homeostasis.
Modulation of epithelial cell adhesion in gastrointestinal homeostasis.
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DOI：
10.1016/s0002-9440(10)65576-9
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发表时间：
1998-08
期刊：
影响因子：
--
通讯作者：
J. Efstathiou;M. Pignatelli
中科院分区：
文献类型：
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作者：
J. Efstathiou;M. Pignatelli
从简单的线虫秀丽隐杆线虫到更复杂的哺乳动物智人，肠道在后生动物体内占据着分化良好的动态活动中心。正常肠上皮细胞动力学的特征在于快速细胞更新，由此来自Lieberkühn隐窝的多能干细胞提供子细胞的恒定供应，这些子细胞沿着隐窝-绒毛轴追求迁移相关分化、极化、增殖、程序性细胞死亡和管腔脱落的成熟途径（图1）。这些过程是维持正常肠上皮结构和功能的基础，并依赖于介导细胞-细胞和细胞基质相互作用的分子。3已鉴定出几个主要的跨膜细胞粘附受体超基因家族：介导相邻细胞之间相互作用的钙粘蛋白;调节与细胞外基质相互作用的整合素;在白细胞和内皮细胞上发现的选择素;以及免疫球蛋白和蛋白聚糖超家族成员。3，4在这篇文章中，我们主要关注上皮钙粘蛋白（E-cadherin）及其相关的细胞骨架伙伴，连环蛋白，以及它们在正常和恢复胃肠上皮细胞行为中的调节作用。我们还考虑了整合素的重要性，并提出了钙粘蛋白和整合素介导的粘附系统之间的串扰的可能性。
From the simple nematode Caenorhabditis elegans to the more complex mammal Homo sapiens, the gut occupies a well differentiated and dynamic center of activity in the metazoan body. Normal intestinal epithelial cell kinetics is characterized by rapid cell turnover whereby pluripotential stem cells from the Lieberkühn’s crypts provide a constant supply of daughter cells that pursue maturation pathways of migration-associated differentiation, polarization, proliferation, programmed cell death, and luminal shedding along the crypt-villus axis (Figure 1). 1, 2 These processes are fundamental for the maintenance of normal intestinal epithelial architecture and function and are dependent on molecules mediating cell-cell and cellmatrix interactions. 3A few main supergene families of transmembrane cellular adhesion receptors have been identified: the cadherins, which mediate interactions between neighboring cells; the integrins, which regulate interactions with the extracellular matrix; the selectins, which are found on leukocytes and endothelial cells; and members of the immunoglobulin and proteoglycan superfamilies. 3, 4 In this article we focus our attention primarily on epithelial cadherin (E-cadherin) and its associated cytoskeletal partners, the catenins, and the regulatory role they play in the behavior of normal and restituting gastrointestinal epithelial cells. We also give some consideration to the importance of integrins and suggest the possibility for cross-talk between the cadherin-and integrin-mediated adhesion systems.