Metabolic syndrome, or What you will: definitions and epidemiology.
Metabolic syndrome, or What you will: definitions and epidemiology.
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DOI：
10.3132/dvdr.2007.003
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发表时间：
2007-03-01
影响因子：
2.4
通讯作者：
Day, Caroline
中科院分区：
文献类型：
--
作者：
Day, Caroline
代谢综合征是一组易使个体发生心血管疾病和死亡的危险因素。关于该综合征的主要组成部分（葡萄糖耐受不良、肥胖、血压升高和血脂异常[甘油三酯升高、高密度脂蛋白胆固醇水平低]）存在普遍共识，但不同的定义需要不同的临界点，并具有不同的强制性纳入标准。虽然胰岛素抵抗被认为是一种主要的病理影响，但只有世界卫生组织（WHO）和欧洲胰岛素抵抗研究小组（EGIR）的定义将其纳入诊断标准，只有国际糖尿病联合会（IDF）的定义将腰围作为强制性组成部分。代谢综合征的患病率在各个队列中随所使用的定义而变化。在每个定义中，代谢综合征的患病率随年龄增加而增加，并因性别和种族而异。不同定义之间缺乏诊断一致性。只有大约30%的人可以被诊断为代谢综合征，使用大多数定义，大约3540%的人被诊断为代谢综合征，仅使用一种定义。目前关于代谢综合征一词的有效性存在争议，但一个心血管危险因素的存在应该引起怀疑，其他危险因素也可能存在，并鼓励调查。应处理个别风险因素。
The metabolic syndrome is a clustering of risk factors which predispose an individual to cardiovascular morbidity and mortality. There is general consensus regarding the main components of the syndrome (glucose intolerance, obesity, raised blood pressure and dyslipidaemia [elevated triglycerides, low levels of high-density lipoprotein cholesterol]) but different definitions require different cut points and have different mandatory inclusion criteria. Although insulin resistance is considered a major pathological influence, only the World Health Organization (WHO) and European Group for the study of Insulin Resistance (EGIR) definitions include it amongst the diagnostic criteria and only the International Diabetes Federation (IDF) definition has waist circumference as a mandatory component. The prevalence of metabolic syndrome within individual cohorts varies with the definition used. Within each definition, the prevalence of metabolic syndrome increases with age and varies with gender and ethnicity. There is a lack of diagnostic concordance between different definitions. Only about 30% of people could be given the diagnosis of metabolic syndrome using most definitions, and about 3540% of people diagnosed with metabolic syndrome are only classified as such using one definition. There is currently debate regarding the validity of the term metabolic syndrome, but the presence of one cardiovascular risk factor should raise suspicion that additional risk factors may also be present and encourage investigation. Individual risk factors should be treated.