Spectral response for laser enhancement in hepatic regeneration for hepatectomized rats
Spectral response for laser enhancement in hepatic regeneration for hepatectomized rats
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DOI：
10.1002/lsm.10141
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发表时间：
2003-01-01
影响因子：
2.4
通讯作者：
Bagnato, VS
中科院分区：
文献类型：
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作者：
Castro-e-Silva, O;Zucoloto, S;Bagnato, VS
背景和目标：低强度激光治疗（LILT）由于其在修复过程、缓解疼痛和生物刺激方面的治疗效果而被广泛应用于各个医学领域。尽管存在用于临床应用的波长的治疗窗口，但是关于对生物效应的频谱响应的研究很少。本研究以Wistar大鼠肝部分切除术后为模型，探讨不同波长的辐射对肝再生的促进作用。研究设计/材料和方法：采用增殖细胞核抗原（PCNA）标记指数和呼吸控制结果与结论：（1）肝细胞线粒体的氧耗率（O2 consumption in extracted mitochondrial）是评价不同波长激光照射后肝再生的指标。结果显示了相关的光谱响应，其可以基于光对生物组织的穿透和所使用的每个波长的生物分子激发效率的组合效应来解释。(C)2003 Wiley-Liss，Inc.
Background and Objectives: The low intensity laser therapy (LILT) has been widely used in all medical fields due to its therapeutic effects in reparative process, pain relief, and biostimulation. Even though there is a therapeutic window of wavelengths for clinical application, little has been done concerning the frequency spectrum response to biological effects. In this work, we investigate the dependence of different wavelengths irradiation in the enhancement of the tissue regeneration after partial hepatectomy in Wistar rats.Study Design/Materials and Methods: The proliferating cell nuclear antigen (PCNA) labeling index and the respiratory control (oxygen consumption in extracted mitochondria) were the tests used to evaluate the liver regeneration after laser irradiation with different wavelengths.Results and Conclusions: The results show a correlated spectral response that can be explained based on the combined effect of light penetration on biological tissues and the biomolecular excitation efficiency for each wavelength used. (C) 2003 Wiley-Liss, Inc.