Extra sex combs buffers sleep-related stresses through regulating Heat shock proteins
Extra sex combs buffers sleep-related stresses through regulating Heat shock proteins
复制标题
额外的性梳通过调节热休克蛋白来缓冲与睡眠相关的压力
DOI：
10.1096/fj.202001303rr
复制
发表时间：
2021
期刊：
影响因子：
4.8
通讯作者：
Juan Du
中科院分区：
文献类型：
--
作者：
Xianguo Zhao;Yahong Li;Zhangwu Zhao;Juan Du
全球变暖对地球生命的影响日益受到关注。此前的研究表明，温度变化对昆虫的睡眠有严重影响。睡眠对动物至关重要，因为它具有许多重要的生理功能。研究温度引起的睡眠变化的调节机制对于了解全球变暖对昆虫的影响具有重要意义。更重要的是，了解这些压力如何调节睡眠可以为改善睡眠提供见解。在这项研究中，我们发现额外的性梳（ESC）是这个过程中的一个调节因素。我们的数据表明ESC是热休克蛋白（Hsps）的上游负调节因子，它可以调节蘑菇和果蝇椭圆体的睡眠。 ESC突变放大了温度引起的睡眠变化，同时缓冲了睡眠不足引起的寿命缩短。这些表型可以通过 Hsps 突变体来挽救。因此，我们得出结论，ESC 通过调节 Hsps 来缓冲与睡眠相关的压力。
The impact of global warming on the life of the earth is increasingly concerned. Previous studies indicated that temperature changes have a serious impact on insect sleep. Sleep is critical for animals as it has many important physiological functions. It is of great significance to study the regulation mechanism of temperature-induced sleep changes for understanding the impact of global warming on insects. More importantly, understanding how these pressures regulate sleep can provide insights into improving sleep. In this study, we found that extra sex combs (ESC) are a regulatory factor in this process. Our data showed that ESC was an upstream negative regulatory factor of Heat shock proteins (Hsps), and it could regulate sleep in mushroom and ellipsoid of Drosophila. ESC mutation exaggerates the sleep change caused by temperature, while buffering the shortening of life caused by sleep deprivation. These phenotypes can be rescued by Hsps mutants. Therefore, we concluded that the ESC buffers sleep-related stresses through regulating Hsps.