The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations.
The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations.
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DOI：
10.1111/pcmr.12498
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发表时间：
2016-09
影响因子：
4.3
通讯作者：
Bosenberg MW
中科院分区：
文献类型：
--
作者：
Meeth K;Wang JX;Micevic G;Damsky W;Bosenberg MW
免疫疗法的显著成功强调了对具有免疫能力的癌症模型的需要。已经建立了各种癌症的基因工程小鼠模型，但其有效使用受到成本和快速生成实验数据的困难的限制。一些小鼠癌细胞系可移植到具有免疫活性的宿主小鼠中，并已被广泛用于研究癌症免疫学。在这里，我们描述了一个全面的系统，小鼠黑色素瘤细胞系是同源的C57 B1/6 J，有明确的人类相关的驱动突变，基因组稳定。这些将是肿瘤免疫学和基因型特异性癌症生物学研究的有用工具。
The remarkable success of immune therapies emphasizes the need for immune competent cancer models. Elegant genetically engineered mouse models of a variety of cancers have been established, but their effective use is limited by cost and difficulties in rapidly generating experimental data. Some mouse cancer cell lines are transplantable to immunocompetent host mice and have been utilized extensively to study cancer immunology. Here we describe a comprehensive system of mouse melanoma cell lines that are syngeneic to C57Bl/6J, have well-defined human-relevant driver mutations, and are genomically stable. These will be a useful tool for the study of tumor immunology and genotype-specific cancer biology.