Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis
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DOI：
10.1038/550s105a
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发表时间：
2017-10
期刊：
影响因子：
64.8
通讯作者：
Brian M. Owens
中科院分区：
文献类型：
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作者：
Brian M. Owens
它开始于小的症状，如肌肉抽搐或无力。最终，肌萎缩侧索硬化症（ALS）剥夺了一个人的所有肌肉控制，导致瘫痪，不能说话，不可避免地死亡。ALS（也称为运动神经元疾病或MND）的原因是未知的。与该疾病相关的基因已被鉴定，包括一个似乎特别重要的基因（C9 ORF 72）（见S106页）。生活方式和环境因素似乎也会影响ALS（S109）。但是研究人员应该警惕过于关注遗传学或环境;两者可以共同导致疾病（S112）。
It begins with small symptoms such as muscle twitches or weakness. Eventually, amyotrophic lateral sclerosis (ALS) robs a person of all muscle control, resulting in paralysis, the inability to speak and, inevitably, death.The cause of ALS (also known as motor neuron disease or MND) is unknown. Genes linked to the disease have been identified, including one (C9ORF72) that seems to be particularly important (see page S106). Lifestyle and environmental factors also seem to influence ALS (S109). But researchers should be wary about too much of a focus on either genetics or the environment; both can work together to bring on the disease (S112).