Chronic alcohol consumption increases the severity of murine influenza virus infections
Chronic alcohol consumption increases the severity of murine influenza virus infections
复制标题
DOI：
10.4049/jimmunol.181.1.641
复制
发表时间：
2008-07-01
影响因子：
4.4
通讯作者：
Legge, Kevin L.
中科院分区：
文献类型：
--
作者：
Meyerholz, David K.;Edsen-Moore, Michelle;Legge, Kevin L.
季节性和潜在大流行性流感病毒的呼吸道感染对人类健康构成重大负担。此外，病毒如流感越来越被认为是社区获得性肺炎的重要病原体。仅在美国，就有1290万人酗酒，长期滥用酒精会增加社区获得性肺炎的风险和严重程度。由于缺乏有关流感疾病的知识，在这一人群中，我们确定了长期饮酒对流感病毒感染的影响。在此，我们报告说，小鼠暴露于慢性乙醇有急剧增加的发病率，死亡率和肺部病毒滴度相对于控制。这些流感严重程度的增加与肺部流感特异性CD8 T细胞应答的抑制相对应。此外，慢性乙醇消耗导致肺部病变严重程度增加，类似于最近描述的大流行性流感。总之，我们的研究结果表明，长期饮酒可能会通过改变肺部炎症环境和CD8 T细胞反应来增加严重流感病毒感染的风险。
Respiratory infections with both seasonal as well as potential pandemic Influenza viruses represent a significant burden on human health. Furthermore, viruses such as Influenza are increasingly recognized as important etiologic agents in community acquired pneumonia. Within the U.S. alone, similar to 12.9 million people are heavy drinkers and chronic abuse of alcohol is known to increase the risk and severity of community acquired pneumonia. Given the lack of knowledge regarding Influenza disease in this population, we determined the effects of chronic alcohol consumption on Influenza virus infection. Herein, we report that mice exposed to chronic ethanol have sharp increases in morbidity, mortality, and pulmonary virus titers relative to controls. These increases in influenza severity correspond with inhibited pulmonary influenza-specific CD8 T cell responses. Further, chronic ethanol consumption results in an enhanced pulmonary lesion severity, similar to that recently described for pandemic influenzas. Together, our results suggest that chronic alcohol consumption may increase the risk for severe influenza virus infections by altering the pulmonary inflammatory environment and CD8 T cell response.