Development of functional gold nanorods for bioimaging and photothermal therapy
Development of functional gold nanorods for bioimaging and photothermal therapy
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DOI：
10.1088/1742-6596/232/1/012011
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发表时间：
2010-06
期刊：
影响因子：
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通讯作者：
T. Niidome
中科院分区：
文献类型：
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作者：
T. Niidome
金纳米棒在近红外光区具有较强的表面等离子体能带，是一种光热转换器。由于近红外光可以深入组织，因此被认为是近红外光生物成像的造影剂、光热疗法的光敏剂和响应近红外光照射的药物传递系统的功能器件。本研究利用配有积分球的分光光度计监测了小鼠腹部静脉注射金纳米棒的表面等离激元谱带，并测定了金纳米棒静脉注射后的药代动力学参数。接下来，将聚乙二醇化修饰的金纳米棒直接注射到小鼠皮下肿瘤中，然后用近红外脉冲激光照射肿瘤。肿瘤损伤明显，肿瘤生长受到抑制。我们构建了金纳米棒的靶向递送系统，通过使用温度响应性聚合物和响应蛋白酶活性的多肽进行修饰。这些修饰的金纳米棒有望成为用于光热治疗和药物输送系统的功能纳米器件。
Gold nanorods have strong surface plasmon band at near-infrared light region, and are used as a photothermal converter. Since the near-infrared light penetrates into tissues deeply, it has been expected as a contrast agent for near infrared light bioimaging, a photosensitizer for photothermal therapy, and functional device for drug delivery system responding to near-infrared light irradiation. In this study, the surface plasmon bands of intravenously injected gold nanorods were monitored in the mouse abdomen using a spectrophotometer equipped with an integrating sphere, then we determined pharmacokinetics parameters of the gold nanorods after intravenous injection. Next, the PEG-modified gold nanorods were directly injected into subcutaneous tumors in mice, then, near-infrared pulsed laser light was irradiated the tumors. Significant tumor damage and suppression of the tumor growth was observed. We constructed targeted delivery system of the gold nanorods by modifying with a thermo-responsive polymer and a peptide responding to a protease activity. These modified gold nanorods are expected as functional nanodevices for photothermal therapy and drug delivery system.